Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
Research ArticleOriginal Article

Factors associated with upstaging in patients preoperatively diagnosed with ductal carcinoma in situ by core needle biopsy

Jing Si, Benlong Yang, Rong Guo, Naisi Huang, Chenlian Quan, Linxiaoxi Ma, Bingqiu Xiu, Yun Cao, Yue Tang, Linxiao Shen, Jiajian Chen and Jiong Wu
Cancer Biology & Medicine May 2019, 16 (2) 312-318; DOI: https://doi.org/10.20892/j.issn.2095-3941.2018.0159
Jing Si
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Benlong Yang
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rong Guo
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naisi Huang
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chenlian Quan
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linxiaoxi Ma
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bingqiu Xiu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yun Cao
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yue Tang
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linxiao Shen
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiajian Chen
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiong Wu
1Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2Department of Oncology, Fudan University, Shanghai Medical College, Shanghai 200032, China
3Collaborative Innovation Center for Cancer Medicine, Shanghai 200032, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

Article Figures & Data

Tables

    • View popup
    1

    Baseline clinicopathological characteristics of the cohort

    CharacteristicsCases (n = 604) %
    Age (years)
    ≤ 5030951.16
    > 5029548.84
    BC family history
    No48179.64
    Yes12320.36
    BMI
    < 2545775.66
    ≥ 2512620.86
    Unknown213.48
    Discharge
    No52086.09
    Yes8413.91
    Tumor size on ultrasonography
    ≤ 2 cm22937.91
    > 2 cm33154.80
    Unknown447.28
    Calcification on mammography
    Yes36360.10
    No7913.08
    Unknown16226.82
    BI-RADS
    360.99
    4A274.47
    4B11519.04
    4C27545.53
    516326.99
    Unknown182.98
    ER
    Negative25442.05
    Positive34056.29
    Unknown101.66
    HER2
    Negative28146.52
    Positive31351.82
    Unknown101.66
    Ki67
    ≤ 14%13622.51
    > 14%41869.20
    Unknown508.29
    Surgical methods
    Mastectomy54890.73
    BCS569.27
    Axillary evaluation
    SLNB51384.93
    ALND9115.07
    Upstaging group
    DCIS29048.01
    DCISM12120.03
    IBC19331.95

    BC, breast cancer; BMI, body mass index; ER, estrogen receptor; HER2, human epidermal growth factor receptor 2; BCS, breast conserving surgery; SLNB, sentinel lymph node biopsy; ALND, axillary lymph node dissection; DCIS, ductal carcinoma in situ; DCISM, ductal carcinoma in situ with microinvasion; IBC, invasive breast cancer.

      • View popup
      2

      Univariate and multivariate analysis of predictive factors of upstaging

      CharacteristicsCases of DCIS
      (n = 290)
      % Cases of DCISM & IBC
      (n = 314)
      % Univariate
      P-value
      Multivariate
      OR (95% CI), P
      Age (years)0.230
      ≤ 5014148.6216853.50
      > 5014951.3814646.50
      BC family history0.229
      No22577.5925681.53
      Yes6522.415818.47
      BMI0.881
      < 2522176.2123675.16
      ≥ 256020.696621.02
      Unknown93.10123.82
      Discharge0.210
      No25587.9326584.39
      Yes3512.074915.61
      Tumor size on ultrasonography0.005
      ≤ 2 cm12743.7910232.48Ref
      > 2 cm13947.9319261.151.558 (1.094-2.218), 0.014
      Unknown248.28206.37
      Calcification on mammography0.169
      Yes16356.2120063.69
      No4114.143812.10
      Unknown8629.667624.20
      BI-RADS0.009
      320.6941.271.207 (0.211-6.912), 0.833
      4A134.48144.460.568 (0.233-1.384), 0.213
      4B6622.764915.610.435 (0.259-0.733), 0.002
      4C14248.9713342.360.502 (0.329-0.764), 0.001
      55920.3410433.12Ref
      Unknown82.76103.18

      DCIS, ductal carcinoma in situ; DCISM, ductal carcinoma in situ with microinvasion; IBC, invasive breast cancer; OR, odd ratio; CI, confidence interval; BC, breast cancer.

        • View popup
        3

        Univariate and multivariate analysis of predictive factors of upstaging to IBC

        CharacteristicsCases of DCIS
        (n = 290)
        %Cases of IBC
        (n = 193)
        %Univariate
        P-value
        Multivariate
        OR (95% CI), P
        Tumor size on ultrasonography0.003
        ≤ 2 cm12743.795930.57Ref
        > 2 cm13947.9312363.731.762 (1.167-2.659), 0.007
        Unknown248.28115.70
        BI-RADS0.022
        320.6921.041.049 (0.139-7.906), 0.963
        4A134.4894.660.506 (0.181-1.410), 0.193
        4B6622.763417.620.520 (0.292-0.926), 0.026
        4C14248.977538.860.459 (0.286-0.738), 0.001
        55920.346634.20Ref
        Unknown82.7673.63

        DCIS, ductal carcinoma in situ; IBC, invasive breast cancer; OR, odd ratio; CI, confidence interval.

        PreviousNext
        Back to top

        In this issue

        Cancer Biology and Medicine: 16 (2)
        Cancer Biology & Medicine
        Vol. 16, Issue 2
        1 May 2019
        • Table of Contents
        • Index by author
        Print
        Download PDF
        Email Article

        Thank you for your interest in spreading the word on Cancer Biology & Medicine.

        NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

        Enter multiple addresses on separate lines or separate them with commas.
        Factors associated with upstaging in patients preoperatively diagnosed with ductal carcinoma in situ by core needle biopsy
        (Your Name) has sent you a message from Cancer Biology & Medicine
        (Your Name) thought you would like to see the Cancer Biology & Medicine web site.
        Citation Tools
        Factors associated with upstaging in patients preoperatively diagnosed with ductal carcinoma in situ by core needle biopsy
        Jing Si, Benlong Yang, Rong Guo, Naisi Huang, Chenlian Quan, Linxiaoxi Ma, Bingqiu Xiu, Yun Cao, Yue Tang, Linxiao Shen, Jiajian Chen, Jiong Wu
        Cancer Biology & Medicine May 2019, 16 (2) 312-318; DOI: 10.20892/j.issn.2095-3941.2018.0159

        Citation Manager Formats

        • BibTeX
        • Bookends
        • EasyBib
        • EndNote (tagged)
        • EndNote 8 (xml)
        • Medlars
        • Mendeley
        • Papers
        • RefWorks Tagged
        • Ref Manager
        • RIS
        • Zotero
        Share
        Factors associated with upstaging in patients preoperatively diagnosed with ductal carcinoma in situ by core needle biopsy
        Jing Si, Benlong Yang, Rong Guo, Naisi Huang, Chenlian Quan, Linxiaoxi Ma, Bingqiu Xiu, Yun Cao, Yue Tang, Linxiao Shen, Jiajian Chen, Jiong Wu
        Cancer Biology & Medicine May 2019, 16 (2) 312-318; DOI: 10.20892/j.issn.2095-3941.2018.0159
        Twitter logo Facebook logo Mendeley logo
        • Tweet Widget
        • Facebook Like
        • Google Plus One

        Jump to section

        • Article
          • Abstract
          • Introduction
          • Materials and methods
          • Results
          • Discussion
          • Conclusions
          • Acknowledgements
          • Conflict of interest statement
          • Footnotes
          • References
        • Figures & Data
        • Info & Metrics
        • References
        • PDF

        Related Articles

        • No related articles found.
        • Google Scholar

        Cited By...

        • The Effect of Smoking on Progression from Ductal Carcinoma In Situ to Invasive Ductal Breast Carcinoma: A Retrospective Study
        • Google Scholar

        More in this TOC Section

        • GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma
        • Comprehensive strategies for management of postoperative hyper-progression recurrence (HPR) of hepatocellular carcinoma: a 12-year large sample multi-center study
        • Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier
        Show more Original Article

        Similar Articles

        Keywords

        • Ductal carcinoma in situ
        • core needle biopsy
        • axillary staging

        Navigate

        • Home
        • Current Issue

        More Information

        • About CBM
        • About CACA
        • About TMUCIH
        • Editorial Board
        • Subscription

        For Authors

        • Instructions for authors
        • Journal Policies
        • Submit a Manuscript

        Journal Services

        • Email Alerts
        • Facebook
        • RSS Feeds
        • Twitter

         

        © 2025 Cancer Biology & Medicine

        Powered by HighWire