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Research ArticleOriginal Article

Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer

Yuxiang Wang, Xian Li, Xueling Liu, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding and Linghua Meng
Cancer Biology & Medicine February 2019, 16 (1) 66-83; DOI: https://doi.org/10.20892/j.issn.2095-3941.2018.0361
Yuxiang Wang
1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Xian Li
1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Xueling Liu
1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Yi Chen
2University of Chinese Academy of Sciences, Beijing 100049, China
3Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Chunhao Yang
4Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200120, China
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Cun Tan
4Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200120, China
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Bobo Wang
1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Yiming Sun
2University of Chinese Academy of Sciences, Beijing 100049, China
3Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Xi Zhang
1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Yinglei Gao
2University of Chinese Academy of Sciences, Beijing 100049, China
3Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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Jian Ding
2University of Chinese Academy of Sciences, Beijing 100049, China
3Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
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  • For correspondence: [email protected] [email protected]
Linghua Meng
1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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  • For correspondence: [email protected] [email protected]
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Cancer Biology & Medicine
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Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
Yuxiang Wang, Xian Li, Xueling Liu, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng
Cancer Biology & Medicine Feb 2019, 16 (1) 66-83; DOI: 10.20892/j.issn.2095-3941.2018.0361

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Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
Yuxiang Wang, Xian Li, Xueling Liu, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding, Linghua Meng
Cancer Biology & Medicine Feb 2019, 16 (1) 66-83; DOI: 10.20892/j.issn.2095-3941.2018.0361
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  • Erratum to Simultaneous inhibition of PI3Ka and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer
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Subjects

  • Lung Cancer

Keywords

  • PI3Kα
  • CDK4/6
  • KRAS
  • NSCLC
  • CYH33

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