Research ArticleOriginal Article

Simultaneous inhibition of PI3Kα and CDK4/6 synergistically suppresses KRAS-mutated non-small cell lung cancer

Yuxiang Wang, Xian Li, Xueling Liu, Yi Chen, Chunhao Yang, Cun Tan, Bobo Wang, Yiming Sun, Xi Zhang, Yinglei Gao, Jian Ding and Linghua Meng
Cancer Biology & Medicine February 2019, 16 (1) 66-83; DOI: https://doi.org/10.20892/j.issn.2095-3941.2018.0361

Article Information

vol. 16 no. 1 66-83
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2018.0361
Published By 
Cancer Biology & Medicine
History 
  • Received September 20, 2018
  • Accepted December 25, 2018
  • Published online February 1, 2019.
Copyright & Usage 
Copyright: © 2019, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Yuxiang Wang1,2,
  2. Xian Li1,
  3. Xueling Liu1,2,
  4. Yi Chen2,3,
  5. Chunhao Yang4,
  6. Cun Tan4,
  7. Bobo Wang1,
  8. Yiming Sun2,3,
  9. Xi Zhang1,
  10. Yinglei Gao2,3,
  11. Jian Ding2,3⇑ and
  12. Linghua Meng1,2⇑
  1. 1Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  2. 2University of Chinese Academy of Sciences, Beijing 100049, China
  3. 3Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
  4. 4Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200120, China
  1. Correspondence to: Jian Ding and Linghua Meng, E-mail: jding{at}simm.ac.cn and lhmeng{at}simm.ac.cn
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