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Review ArticleReview

PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy

Long Jia, Qi Zhang and Rongxin Zhang
Cancer Biology & Medicine May 2018, 15 (2) 116-123; DOI: https://doi.org/10.20892/j.issn.2095-3941.2017.0086
Long Jia
1Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Key Laboratory of Immune Microenvironments and Diseases of Educational Ministry, Tianjin Medical University, Tianjin 300070, China
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Qi Zhang
2Institute of Integrative Medicines for Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin 300100, China
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Rongxin Zhang
1Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Key Laboratory of Immune Microenvironments and Diseases of Educational Ministry, Tianjin Medical University, Tianjin 300070, China
3Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
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  • For correspondence: rxzhang{at}tmu.edu.cn rongxinz{at}yahoo.com
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Article Information

vol. 15 no. 2 116-123
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2017.0086

Published By 
Cancer Biology & Medicine
History 
  • Received July 15, 2017
  • Accepted February 1, 2018
  • Published online May 1, 2018.

Copyright & Usage 
Copyright: © 2018, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Long Jia1,
  2. Qi Zhang2 and
  3. Rongxin Zhang⇑1,3
  1. 1Laboratory of Immunology and Inflammation, Department of Immunology and Research Center of Basic Medical Sciences, Key Laboratory of Immune Microenvironments and Diseases of Educational Ministry, Tianjin Medical University, Tianjin 300070, China
  2. 2Institute of Integrative Medicines for Acute Abdominal Diseases, Tianjin Nankai Hospital, Tianjin 300100, China
  3. 3Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
  1. Correspondence to: Rongxin Zhang, E-mail: rxzhang{at}tmu.edu.cn or rongxinz{at}yahoo.com
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Cancer Biology and Medicine: 15 (2)
Cancer Biology & Medicine
Vol. 15, Issue 2
1 May 2018
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PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy
Long Jia, Qi Zhang, Rongxin Zhang
Cancer Biology & Medicine May 2018, 15 (2) 116-123; DOI: 10.20892/j.issn.2095-3941.2017.0086

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PD-1/PD-L1 pathway blockade works as an effective and practical therapy for cancer immunotherapy
Long Jia, Qi Zhang, Rongxin Zhang
Cancer Biology & Medicine May 2018, 15 (2) 116-123; DOI: 10.20892/j.issn.2095-3941.2017.0086
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  • Article
    • Abstract
    • Introduction
    • Clinical studies of PD-1/PD-L1 blocking drugs
    • Universality and sustainability
    • Can higher cut-off standards promote the ability of PD-L1 to function as an indicative marker?
    • Safety
    • Combination therapies
    • Future prospective
    • Footnotes
    • References
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Keywords

  • PD-1
  • PD-L1
  • cancer immunotherapy

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