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Research ArticleOriginal Article

EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation

Yang Chen, Youyou Wang, Lujun Zhao, Ping Wang, Jifeng Sun, Rudi Bao, Chenghai Li and Ningbo Liu
Cancer Biology & Medicine February 2018, 15 (1) 39-51; DOI: https://doi.org/10.20892/j.issn.2095-3941.2017.0118
Yang Chen
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Youyou Wang
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Lujun Zhao
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Ping Wang
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Jifeng Sun
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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Rudi Bao
2Jiangsu Hansoh Pharmaceutical Co., Ltd, Lianyungang 222069, China
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Chenghai Li
2Jiangsu Hansoh Pharmaceutical Co., Ltd, Lianyungang 222069, China
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Ningbo Liu
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin; Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: tj_liuningbo{at}163.com
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EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation
Yang Chen, Youyou Wang, Lujun Zhao, Ping Wang, Jifeng Sun, Rudi Bao, Chenghai Li, Ningbo Liu
Cancer Biology & Medicine Feb 2018, 15 (1) 39-51; DOI: 10.20892/j.issn.2095-3941.2017.0118

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EGFR tyrosine kinase inhibitor HS-10182 increases radiation sensitivity in non-small cell lung cancers with EGFR T790M mutation
Yang Chen, Youyou Wang, Lujun Zhao, Ping Wang, Jifeng Sun, Rudi Bao, Chenghai Li, Ningbo Liu
Cancer Biology & Medicine Feb 2018, 15 (1) 39-51; DOI: 10.20892/j.issn.2095-3941.2017.0118
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Keywords

  • HS-10182
  • radiosensitization
  • NSCLC
  • EGFR-TKI
  • T790M mutation
  • radiosensitivity

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