EditorialEditorial

The evolution of Epstein-Barr virus detection in nasopharyngeal carcinoma

You Quan Li, Ni Sann Khin and Melvin L.K. Chua
Cancer Biology & Medicine February 2018, 15 (1) 1-5; DOI: https://doi.org/10.20892/j.issn.2095-3941.2017.0176

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    Summary of NPC screening studies.

    StudySample sizeScreening markerResults
    Zeng et al.712,932VCA/IgA and EA/IgA39 NPC detected;
    PPV for VCA/IgA & EA/IgA 1.0%;
    PPV for VCA/IgA 1.9%
    Zong et al.852,450VCA/IgA136 NPC detected;
    Sensitivity 97.84%;
    Specificity 93.59%;
    PPV 4.82%;
    NPV 99.99%
    Chien et al.99,699VCA/IgA and EBV DNase neutralising22 NPC detected;
    Sensitivity of VCA/IgA 18%;
    Specificity of VCA/IgA 98%;
    PPV of VCA/IgA 3%;
    NPV of VCA/IgA 99%
    Sensitivity of Anti-EBV DNAse 31%;
    Specificity of Anti-EBV DNAse 88%;
    PPV of Anti-EBV DNAse 0.6%;
    NPV of Anti-EBV DNAse 99%
    Cao et al.1018,986VCA/IgA & EA/IgA125 NPC detected;
    Sensitivity 33.6%;
    Specificity 93.0%;
    PPV 3.0%;
    NPV 99.5%
    Ji et al.17862EBNA1/IgA & VCA/IgA; EBV DNA33 NPC detected;
    Sensitivity of EBV DNA 86.8%;
    Specificity of EBV DNA 90%;
    PPV of EBV DNA 30%;
    NPV of EBV DNA 99.3%
    Chan et al.161,318VCA/IgA & EBV DNA3 NPC detected;
    Sensitivity of EBV DNA 100%;
    Specificity of EBV DNA 98.7%;
    PPV of EBV DNA 15%;
    NPV of EBV DNA 100%
    Chan et al.1820,174EBV DNA34 NPC detected;
    Sensitivity 97.1%;
    Specificity 98.6%;
    PPV 11.0%;
    NPV 99.9%

    PPV: positive predictive value; NPV: negative predictive value.

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