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Review ArticleReview

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

Spiros A. Vlahopoulos
Cancer Biology & Medicine August 2017, 14 (3) 254-270; DOI: https://doi.org/10.20892/j.issn.2095-3941.2017.0029
Spiros A. Vlahopoulos
1The First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens 11527, Greece
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Cancer Biology and Medicine: 14 (3)
Cancer Biology & Medicine
Vol. 14, Issue 3
1 Aug 2017
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Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
Spiros A. Vlahopoulos
Cancer Biology & Medicine Aug 2017, 14 (3) 254-270; DOI: 10.20892/j.issn.2095-3941.2017.0029

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Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
Spiros A. Vlahopoulos
Cancer Biology & Medicine Aug 2017, 14 (3) 254-270; DOI: 10.20892/j.issn.2095-3941.2017.0029
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  • Article
    • Abstract
    • Introduction
    • Cycle of NF-κB activity
    • Molecular types induced by NF-κB
    • Operating mode of NF-κB
    • Loss of feedback to NF-κB affects tissue homeostatic coordination
    • Interacting agents of NF-κB direct immune system activity
    • Intracellular and extracellular cancer processes
    • Modulation of the microenvironment to “license” cancer: many processes initiated by a few genes
    • NF-κB target gene regulation is tissue dependent
    • Conclusions
    • Acknowledgements
    • Footnotes
    • References
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Keywords

  • Cytokine
  • mucin
  • chemokine
  • IL-8/CXCL8
  • MUC1
  • NF-κB
  • IL-6
  • TNFα

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