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Review ArticleReview

Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode

Spiros A. Vlahopoulos
Cancer Biology & Medicine August 2017, 14 (3) 254-270; DOI: https://doi.org/10.20892/j.issn.2095-3941.2017.0029
Spiros A. Vlahopoulos
1The First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens 11527, Greece
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  • For correspondence: v_spiros{at}hotmail.com
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Article Information

vol. 14 no. 3 254-270
DOI 
https://doi.org/10.20892/j.issn.2095-3941.2017.0029

Published By 
Cancer Biology & Medicine
History 
  • Received March 18, 2017
  • Accepted June 8, 2017
  • Published online August 1, 2017.

Copyright & Usage 
Copyright: © 2017, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Author Information

  1. Spiros A. Vlahopoulos⇑1
  1. 1The First Department of Pediatrics, University of Athens, Horemeio Research Laboratory, Athens 11527, Greece
  1. Correspondence to: Spiros A. Vlahopoulos, E-mail: v_spiros{at}hotmail.com
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Cancer Biology and Medicine: 14 (3)
Cancer Biology & Medicine
Vol. 14, Issue 3
1 Aug 2017
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Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
Spiros A. Vlahopoulos
Cancer Biology & Medicine Aug 2017, 14 (3) 254-270; DOI: 10.20892/j.issn.2095-3941.2017.0029

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Aberrant control of NF-κB in cancer permits transcriptional and phenotypic plasticity, to curtail dependence on host tissue: molecular mode
Spiros A. Vlahopoulos
Cancer Biology & Medicine Aug 2017, 14 (3) 254-270; DOI: 10.20892/j.issn.2095-3941.2017.0029
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  • Article
    • Abstract
    • Introduction
    • Cycle of NF-κB activity
    • Molecular types induced by NF-κB
    • Operating mode of NF-κB
    • Loss of feedback to NF-κB affects tissue homeostatic coordination
    • Interacting agents of NF-κB direct immune system activity
    • Intracellular and extracellular cancer processes
    • Modulation of the microenvironment to “license” cancer: many processes initiated by a few genes
    • NF-κB target gene regulation is tissue dependent
    • Conclusions
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
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Keywords

  • Cytokine
  • mucin
  • chemokine
  • IL-8/CXCL8
  • MUC1
  • NF-κB
  • IL-6
  • TNFα

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