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Review ArticleReview

Epidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China

He Liang, Jin-Hu Fan and You-Lin Qiao
Cancer Biology & Medicine February 2017, 14 (1) 33-41; DOI: https://doi.org/10.20892/j.issn.2095-3941.2016.0093
He Liang
1Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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Jin-Hu Fan
1Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • For correspondence: fanjh{at}cicams.ac.cn qiaoy{at}cicams.ac.cn
You-Lin Qiao
1Department of Cancer Epidemiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • For correspondence: fanjh{at}cicams.ac.cn qiaoy{at}cicams.ac.cn
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    Age-adjusted incidence rates for esophageal cancer according to region and gender in China, 2012.

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    Age-adjusted mortality for esophageal cancer according to regions and gender in China, 2012.

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    Trends in incidence rates (ASR) for esophageal cancer in China from 2000 to 2011.

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    Trends in mortality rates (ASR) for esophageal cancer in China from 2000 to 2011.

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    Screening strategy of esophageal cancer in high-risk areas of China

    Population40–69 years old high risk population
    MethodEndoscopy + iodine staining+ indicative biopsy
    Pathologic diagnostic criteria
     Mild dysplasiaAtypical cells are distributed mainly in the basement membrane, less than 1/3 of the epithelium
     Moderate dysplasiaAtypical cells are involved in the top layer of epithelium or less than 2/3 of the epithelium
     SD/CISPrecursor lesions involve the epithelium without invading the basement membrane; atypical cells are fully or almost fully distributed in the epithelium with a clear structure of the basement membrane
     Intramucosal carcinomaLamina propria is invaded and restricted to the mucosa layer; the rate of lymph node metastasis rate ranges from 1% to 5%
     Submucosal carcinomaSubmucosa is invaded; muscular layer of esophagus is not invaded; the rate of lymph node metastasis ranges from 10% to 50%
    Treatment and follow-up
     Mild dysplasia/moderate dysplasiaInterventions such as nutrition or medication can be taken, affecting their differentiation in its reversal Follow-up for these patients should be conducted every 3-5 years
     SD/CIS and intramucosal carcinomaThese patients should receive the treatment of EMR/APC. Follow-up should also be conducted annually
     Submucosal carcinomaThese patients should receive the Esophagectomy. Esophagectomy should also be conducted for patients with SD/CIS or intramucosal carcinoma and the lesion is large than 3 cm in diameter or invasion of esophageal circumference 3/4
     In advanced esophageal cancerStandard treatments, such as surgery, radiotherapy and chemotherapy should be used according to the conditions of patients

    SD: sever dysplasia; CIS: carcinoma in situ; EMA: endoscopic mucosal resection; APC: argon plasma coagulation.

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    Cancer Biology and Medicine: 14 (1)
    Cancer Biology & Medicine
    Vol. 14, Issue 1
    1 Feb 2017
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    Epidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China
    He Liang, Jin-Hu Fan, You-Lin Qiao
    Cancer Biology & Medicine Feb 2017, 14 (1) 33-41; DOI: 10.20892/j.issn.2095-3941.2016.0093

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    Epidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China
    He Liang, Jin-Hu Fan, You-Lin Qiao
    Cancer Biology & Medicine Feb 2017, 14 (1) 33-41; DOI: 10.20892/j.issn.2095-3941.2016.0093
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    Keywords

    • epidemiology
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    • esophageal squamous cell carcinoma
    • review

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