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Case ReportCase Report

Work-up and management of a high-risk patient with primary central nervous system lymphoma

Pervin A. Zeynalova, Gayane S. Tumyan, Mikhail B. Dolgushin and Mobil I. Akhmedov
Cancer Biology & Medicine December 2016, 13 (4) 514-518; DOI: https://doi.org/10.20892/j.issn.2095-3941.2016.0070
Pervin A. Zeynalova
1Division of Hematology and Bone Marrow Transplantation
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Gayane S. Tumyan
1Division of Hematology and Bone Marrow Transplantation
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Mikhail B. Dolgushin
2Department of Nuclear Medicine and Molecular Imaging, N.N. Blokhin Russian Cancer Research Center, Moscow 115478, Russia
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Mobil I. Akhmedov
1Division of Hematology and Bone Marrow Transplantation
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    1

    PET/CT scan. FDG uptake by the 2.4 cm × 1.4 cm mass in the left cerebellum hemisphere with maximal SUV 40.67 and spinal cord FDG uptake at the Th11-S2 level with max SUV 13.05.

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    2

    Contrast-enhanced MRI(A, B) and MRI(C). T2, T2-flair, and DWI regimens revealed lesions of 2.8 cm × 1.6 cm and 1.0 cm in left hemisphere of cerebellum (white arrows).

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    Cytology examination of CSF. Large centroblastic-type cells with high mitosis frequency are strongly suspicious for lymphoma (H&E staining, 200×).

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    4

    Immunophenotyping of CSF. Fifty-five percent of cells correspond to k-clonal, CD5, CD10 - negative, CD19, CD20, CD45 - positive B-cell lymphocytes indicating DLBCL.

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    Control MRI. Distal (A) and proximal (B) slice demonstrating decrease of primary lesions (white arrows) to 1.9 cm × 1.0 cm and 0.3 cm × 0.4 cm, respectively.

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    6

    (A) Initial CT scan demonstrating a 3.0 cm × 2.0 cm lesion in the S10 of the right lung (white arrow) suspicious for aspergillus. (B) CT scan after treatment with voriconazole demonstrating almost total regress of the lesion (white arrow).

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Cancer Biology and Medicine: 13 (4)
Cancer Biology & Medicine
Vol. 13, Issue 4
1 Dec 2016
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Work-up and management of a high-risk patient with primary central nervous system lymphoma
Pervin A. Zeynalova, Gayane S. Tumyan, Mikhail B. Dolgushin, Mobil I. Akhmedov
Cancer Biology & Medicine Dec 2016, 13 (4) 514-518; DOI: 10.20892/j.issn.2095-3941.2016.0070

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Work-up and management of a high-risk patient with primary central nervous system lymphoma
Pervin A. Zeynalova, Gayane S. Tumyan, Mikhail B. Dolgushin, Mobil I. Akhmedov
Cancer Biology & Medicine Dec 2016, 13 (4) 514-518; DOI: 10.20892/j.issn.2095-3941.2016.0070
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Keywords

  • Brain neoplasms
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