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Research ArticleOriginal Article

Surgical treatment of intrahepatic cholangiocarcinoma: a retrospective study of 104 cases

Xiao-Dong Xun and Qiang Li
Cancer Biology & Medicine December 2016, 13 (4) 469-473; DOI: https://doi.org/10.20892/j.issn.2095-3941.2016.0063
Xiao-Dong Xun
1Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
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Qiang Li
1Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
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  • For correspondence: liqiang4016{at}yahoo.com
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    1

    Survival curves of patients in the HLL group and NL group.

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    1

    Summary of clinicopathological features of ICC, n (%)

    CharacteristicsHLLEHLLNL
    Gender
     Female12 (57.1)8 (66.7)27 (38.0)
     Male9 (42.9)4 (33.3)44 (62.0)
    Age, years
     ≤6015 (71.4)6 (50.0)41 (57.7)
     >606 (28.6)6 (50.0)30 (42.3)
    Tumor number
     Solitary12 (57.1)9 (75.0)41 (57.7)
     Multiple9 (42.9)3 (25.0)30 (42.3)
    Tumor diameter, cm
     ≤56 (28.6)4 (33.3)40 (56.3)
     >515 (71.4)8 (66.7)31 (43.7)
    Hepatitis B
     Negative11 (52.4)10 (83.3)38 (53.5%)
     Positive10 (47.6)2 (16.7)33 (46.5)
    Cirrhosis
     Negative16 (76.2)12 (100.0)39 (54.9)
     Positive5 (23.8)0 (0.0)32 (45.1)
    Fer
     Normal6 (28.6)6 (50.0)41 (57.7)
     Higher15 (71.4)6 (50.0)30 (42.3)
    CEA
     Normal13 (61.9)8 (66.7)62 (87.3)
     Higher8 (38.1)4 (33.3)9 (12.7)
    CA19-9
     Normal5 (23.8)2 (16.7)48 (67.6)
     Higher16 (76.2)10 (83.3)23 (32.4)
    AFP
     Normal20 (95.2)11 (91.7)50 (70.4)
     Higher1 (4.8)1 (8.3)21 (29.6)
    AJCC stage
     I/II10 (47.6)9 (75.0)49 (69.0)
     III/IVa/IVb11 (52.4)3 (25.0)22 (31.0)
    Differentiation
     Poor7 (33.3)7 (58.3)40 (56.3)
     Well or moderate14 (66.7)5 (41.7)31 (43.7)
    Vascular invasion
     Negative13 (61.9)8 (66.7)48 (67.6)
     Positive8 (38.1)4 (33.3)23 (32.4)
    LNM
     Negative15 (71.4)7 (58.3)71 (100.0)
     Positive6 (28.6)5 (41.7)0 (0.0)
    • View popup
    2

    Comparison of the OS according to the LND

    LNDHLLEHLLNL
    Chi-squarePChi-squarePChi-squareP
    HLL--2.8550.0916.3450.012
    EHLL2.8550.091--0.0020.969
    NL6.3450.0120.0020.969--
    • View popup
    3

    Results of univariate analysis

    CharacteristicnSurvival rate (%)P
    1 year2 years3 years
    Gender0.028
     Female4768.144.031.1
     Male5775.466.053.2
    Age, years0.041
     ≤606275.862.454.3
     >604266.746.727.6
    Tumor number0.503
     Solitary6275.858.844.0
     Multiple4266.752.443.7
    Tumor diameter, cm0.059
     ≤55076.060.953.7
     >55468.548.932.4
    Hepatitis B0.896
     Negative5974.656.844.1
     Positive4568.952.443.0
    Liver cirrhosis0.649
     Negative6771.656.244.7
     Positive3773.052.641.4
    Fer0.010
     Normal5383.067.255.9
     Higher5160.842.031.5
    CEA0.042
     Normal8375.960.646.5
     Higher2157.138.131.7
    CA-1990.038
     Normal5580.062.452.5
     Higher4963.346.234.6
    AFP0.632
     Normal8170.454.843.7
     Higher2378.360.644.2
    AJCC stage0.000
     I/II6882.471.154.0
     III/IVa/IVb3652.827.823.8
    Differentiation0.009
     Poor5468.548.728.4
     Well or moderate5076.063.659.9
    Vascular invasion0.689
     Negative6971.055.942.5
     Positive3574.356.146.8
    LNM0.003
     Negative9376.359.547.8
     Positive1136.427.30
    LND0.032
     HLL2147.628.628.6
     EHLL1275.066.733.3
     NL7178.962.547.8
    • View popup
    4

    Results of multivariate analysis

    Clinical featuresBWaldPExp (B)Exp (B) 95% CI
    Age– 0.6074.841<0.050.545(0.317, 0.936)
    AJCC stage– 0.94811.510<0.050.388(0.224, 0.670)
    Differentiation0.6024.494<0.051.825(1.046, 3.182)
    Fer0.6745.530<0.051.962(1.119, 3.439)
    LNM1.0727.307<0.052.921(1.343, 6.353)
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Cancer Biology and Medicine: 13 (4)
Cancer Biology & Medicine
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Surgical treatment of intrahepatic cholangiocarcinoma: a retrospective study of 104 cases
Xiao-Dong Xun, Qiang Li
Cancer Biology & Medicine Dec 2016, 13 (4) 469-473; DOI: 10.20892/j.issn.2095-3941.2016.0063

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Surgical treatment of intrahepatic cholangiocarcinoma: a retrospective study of 104 cases
Xiao-Dong Xun, Qiang Li
Cancer Biology & Medicine Dec 2016, 13 (4) 469-473; DOI: 10.20892/j.issn.2095-3941.2016.0063
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Keywords

  • Intrahepatic cholangiocarcinoma
  • surgical treatment
  • lymph node dissection
  • prognosis

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