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Case ReportCase Report

Primary peritoneal carcinoma metastasizing to breast: a single case report and literature review from clinic to biology

Ji-Yuan Sun, Wondwossen Gebre, Yi-Min Dong, Xiao Shaun, Rachel Robbins and Alida Podrumar
Cancer Biology & Medicine September 2016, 13 (3) 389-395; DOI: https://doi.org/10.20892/j.issn.2095-3941.2016.0058
Ji-Yuan Sun
1Department of Internal Medicine, Nassau University Medical Center, East Meadow, New York 11554, USA
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  • For correspondence: ssmu{at}hotmail.com
Wondwossen Gebre
2Department of Pathology, Nassau University Medical Center, East Meadow, New York 11554, USA
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Yi-Min Dong
3Department of Pathology, University of Arizona, Tucson, Arizona 85721, USA
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Xiao Shaun
1Department of Internal Medicine, Nassau University Medical Center, East Meadow, New York 11554, USA
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Rachel Robbins
2Department of Pathology, Nassau University Medical Center, East Meadow, New York 11554, USA
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Alida Podrumar
1Department of Internal Medicine, Nassau University Medical Center, East Meadow, New York 11554, USA
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    1

    CT scans of metastatic cancer with unknown primary site. (A) Large volume of intra-abdominal ascites with a large hypodense mass in the right abdomen measuring approximately 24.1 × 16.3 × 7.9 cm. (B) A 3.6 × 2.4 cm mass-like density in anterior aspect of gastric antrum. (C) A 2.6 × 1.5 cm mass on the lateral aspect of the descending colon. (D) Two masses, including a 4.4 × 2.3 cm eccentric mass along the sigmoid colon without complete obstruction. (E) A superior diaphragmatic lymphadenopathy around 1.8 × 1.1 cm. (F) Peripancreatic adenopathy measuring up to 1.9 × 1.8 cm.

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    2

    CT scans and mammogram of worsening metastatic disease since the prior study. (A) A poorly defined hypodense mass, 4.1 × 3.3 cm, in the left lobe of the liver suspicious for metastasis. (B) Two right axillary enlarged lymph nodes, measuring around 2 × 1 × 1 cm. (C) Mammogram showed a 0.8 × 0.7 × 0.8 cm nodule in the right breast on craniocaudal (CC) view.

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    3

    Immunochemical and histological appearance of primary peritoneal cancer metastasized to breast. (A) Right breast lumpectomy showed metastatic breast cancer from unknown primary (H&E, 200×). (B) Metastasis was also found in right axillary node (H&E, 200×). (C) WT1 was highly expressed in metastatic breast cancer (IHC, 40×). (D) PAX8 was also highly expressed in metastatic breast cancer (IHC, 40×). (E) No expression of mammoglobin in metastatic breast cancer (IHC, 40×). (F) No expression of GATA3 in metastatic breast cancer (IHC, 40×).

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    4

    Molecular markers to distinguish undifferentiated carcinoma.

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Cancer Biology and Medicine: 13 (3)
Cancer Biology & Medicine
Vol. 13, Issue 3
1 Sep 2016
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Primary peritoneal carcinoma metastasizing to breast: a single case report and literature review from clinic to biology
Ji-Yuan Sun, Wondwossen Gebre, Yi-Min Dong, Xiao Shaun, Rachel Robbins, Alida Podrumar
Cancer Biology & Medicine Sep 2016, 13 (3) 389-395; DOI: 10.20892/j.issn.2095-3941.2016.0058

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Primary peritoneal carcinoma metastasizing to breast: a single case report and literature review from clinic to biology
Ji-Yuan Sun, Wondwossen Gebre, Yi-Min Dong, Xiao Shaun, Rachel Robbins, Alida Podrumar
Cancer Biology & Medicine Sep 2016, 13 (3) 389-395; DOI: 10.20892/j.issn.2095-3941.2016.0058
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Keywords

  • Primary peritoneal cancer
  • Breast cancer
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  • WT1
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