Skip to main content

Main menu

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Other Publications
    • cbm

User menu

  • My alerts

Search

  • Advanced search
Cancer Biology & Medicine
  • Other Publications
    • cbm
  • My alerts
Cancer Biology & Medicine

Advanced Search

 

  • Home
  • About
    • About CBM
    • Editorial Board
    • Announcement
  • Articles
    • Ahead of print
    • Current Issue
    • Archive
    • Collections
    • Cover Story
  • For Authors
    • Instructions for Authors
    • Resources
    • Submit a Manuscript
  • For Reviewers
    • Become a Reviewer
    • Instructions for Reviewers
    • Resources
    • Outstanding Reviewer
  • Subscription
  • Alerts
    • Email Alerts
    • RSS Feeds
    • Table of Contents
  • Contact us
  • Follow cbm on Twitter
  • Visit cbm on Facebook
Research ArticleOriginal Article

Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies

Wei Liao and Sanjai Sharma
Cancer Biology & Medicine June 2016, 13 (2) 277-285; DOI: https://doi.org/10.20892/j.issn.2095-3941.2016.0026
Wei Liao
1Division of Hematology-Oncology, Greater Los Angeles VA Healthcare Center, UCLA School of Medicine, Los Angeles, CA 90073, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sanjai Sharma
1Division of Hematology-Oncology, Greater Los Angeles VA Healthcare Center, UCLA School of Medicine, Los Angeles, CA 90073, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: sasharma{at}mednet.ucla.edu
  • Article
  • Figures & Data
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Wickremasinghe RG,
    2. Prentice AG,
    3. Steele AJ.
    Aberrantly activated anti-apoptotic signalling mechanisms in chronic lymphocytic leukaemia cells: clues to the identification of novel therapeutic targets. Br J Haematol. 2011; 153: 545–56.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Stevenson FK,
    2. Krysov S,
    3. Davies AJ,
    4. Steele AJ,
    5. Packham G.
    B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2011; 118: 4313–20.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Burger JA,
    2. Gribben JG.
    The microenvironment in chronic lymphocytic leukemia (CLL) and other B-cell malignancies: insight into disease biology and new targeted therapies. Semin Cancer Biol. 2014; 24: 71–81.
    OpenUrlCrossRefPubMed
  4. 4.↵
    1. Burger JA,
    2. Tsukada N,
    3. Burger M,
    4. Zvaifler NJ.
    5. Dell'aquila M,
    6. kipps TJ.
    Blood-derived nurse-like cells protect chronic lymphocytic leukemia B-cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood. 2000; 96: 2655–63.
    OpenUrlAbstract/FREE Full Text
  5. 5.↵
    1. Krysov S,
    2. Dias S,
    3. Paterson A,
    4. Mockridge CI,
    5. Potter KN,
    6. Smith KA, et al.
    Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells. Blood. 2012; 119: 170–9.
    OpenUrlAbstract/FREE Full Text
  6. 6.
    1. Fecteau JF,
    2. Bharati IS.
    3. O'hayre M,
    4. Handel TM,
    5. Kipps TJ,
    6. Messmer D.
    Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cellleukemia sequence 1(Mcl-1). Mol Med. 2012; 18: 19–28.
    OpenUrlPubMed
  7. 7.
    1. Yaktapour N,
    2. Meiss F,
    3. Mastroianni J,
    4. Zenz T,
    5. Andrlova H,
    6. Mathew NR, et al.
    BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. J Clin Invest. 2014; 124: 5074–84.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Bailón E,
    2. Ugarte-Berzal E,
    3. Amigo-Jiménez I,
    4. Van Den Steen P,
    5. Opdenakker G,
    6. García-Marco JA, et al.
    Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014; 96: 185–99.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Marzo I,
    2. Pérez-Galán P,
    3. Giraldo P,
    4. López-Royuela N,
    5. Gómez-Benito M,
    6. Larrad L, et al.
    Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells. Leukemia. 2004; 18: 1599–604.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Bos JL,
    2. Rehmann H,
    3. Wittinghofer A.
    GEFs and GAPs: critical elements in the control of small G proteins. Cell. 2007; 129: 865–77.
    OpenUrlCrossRefPubMedWeb of Science
  11. 11.↵
    1. Fernández-Medarde A,
    2. Santos E.
    The RasGrf family of mammalian guanine nucleotide exchange factors. Biochim Biophys Acta. 2011; 1815: 170–88.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Vigil D,
    2. Cherfils J,
    3. Rossman KL,
    4. Der CJ.
    Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer. 2010; 10: 842–57.
    OpenUrlCrossRefPubMedWeb of Science
  13. 13.↵
    1. Liao W,
    2. Jordaan G,
    3. Coriaty N,
    4. Sharma S.
    Amplification of B-cell receptor-ERK signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia. Leuk Lymphoma. 2014; 55: 2907–16.
    OpenUrl
  14. 14.
    1. Zheng Y,
    2. Quilliam LA.
    Activation of the Ras superfamily of small GTPases. Workshop on exchange factors. EMBO Rep. 2003; 4: 463-8.
    OpenUrlFREE Full Text
  15. 15.↵
    1. Costello PS,
    2. Walters AE,
    3. Mee PJ,
    4. Turner M,
    5. Reynolds LF,
    6. Prisco A, et al.
    The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the Calcium, ERK, and NF-kappaB pathways. Proc Natl Acad Sci U S A. 1999; 96: 3035–40.
    OpenUrlAbstract/FREE Full Text
  16. 16.
    1. Ebinu JO,
    2. Stang SL,
    3. Teixeira C,
    4. Bottorff DA,
    5. Hooton J,
    6. Blumberg PM, et al.
    RasGRP links T-cell receptor signaling to Ras. Blood. 2000; 95: 3199–203.
    OpenUrlAbstract/FREE Full Text
  17. 17.↵
    1. Stone JC.
    Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells. Genes Cancer 2011; 2: 320–34.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Zhu TN,
    2. He HJ,
    3. Kole S,
    4. D'souza T,
    5. Agarwal R,
    6. Morin PJ, et al.
    Filamin a-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells. J Biol Chem. 2007; 282: 14816–26.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Longo PG,
    2. Laurenti L,
    3. Gobessi S,
    4. Sica S,
    5. Leone G,
    6. Efremov DG.
    The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B-cells. Blood. 2008; 111: 846–55.
    OpenUrlAbstract/FREE Full Text
  20. 20.
    1. Buchner M,
    2. Fuchs S,
    3. Prinz G,
    4. Pfeifer D,
    5. Bartholomé K,
    6. Burger M, et al.
    Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res. 2009; 69: 5424–32.
    OpenUrlAbstract/FREE Full Text
  21. 21.
    1. Herman SE,
    2. Gordon AL,
    3. Hertlein EA,
    4. Zhang XL,
    5. Jaglowski S,
    6. Flynn J, et al.
    Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood. 2011; 117: 6287–96.
    OpenUrlAbstract/FREE Full Text
  22. 22.↵
    1. Talab F,
    2. Allen JC,
    3. Thompson V,
    4. Lin K,
    5. Slupsky JR.
    LCK is an important mediator of B-cell receptor signaling in chronic lymphocytic leukemia cells. Mol Cancer Res. 2013; 11: 541–54.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Burger JA,
    2. Kipps TJ.
    Chemokine receptors and stromal cells in the homing and homeostasis of chronic lymphocytic leukemia B-cells. Leuk Lymphoma. 2002; 43: 461–6.
    OpenUrlCrossRefPubMedWeb of Science
  24. 24.
    1. Bürkle A,
    2. Niedermeier M,
    3. Schmitt-Grff A,
    4. Wierda WG,
    5. Keating MJ,
    6. Burger JA.
    Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood. 2007; 110: 3316–25.
    OpenUrlAbstract/FREE Full Text
  25. 25.↵
    1. Messmer D,
    2. Fecteau JF,
    3. O'Hayre M,
    4. Bharati IS,
    5. Handel TM,
    6. Kipps TJ.
    Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 2011; 117: 882–9.
    OpenUrlAbstract/FREE Full Text
  26. 26.
    1. Mittal AK,
    2. Chaturvedi NK,
    3. Rai KJ,
    4. Gilling-Cutucache CE,
    5. Nordgren TM,
    6. Moragues M, et al.
    Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease. Mol Med. 2014; 20: 290–301.
    OpenUrlCrossRefPubMed
  27. 27.↵
    1. Burger JA,
    2. Ghia P,
    3. Rosenwald A,
    4. Caligaris-Cappio F.
    The microenvironment in mature B-cell malignancies: a target for new treatment strategies. Blood. 2009; 114: 3367–75.
    OpenUrlAbstract/FREE Full Text
  28. 28.↵
    1. Nwabo Kamdje AH,
    2. Mosna F,
    3. Bifari F,
    4. Lisi V,
    5. Bassi G,
    6. Malpeli G, et al.
    Notch-3 and notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells. Blood. 2011; 118: 380–9.
    OpenUrlAbstract/FREE Full Text
  29. 29.↵
    1. Kamga PT,
    2. Kamdje AHN.
    Signaling pathways in leukemia:any role for medicinal plants in leukemia therapy. J Dis Med Plant. 2015; 1: 76–9.
    OpenUrl
  30. 30.↵
    1. Zamò A,
    2. Ott G,
    3. Katzenberger T,
    4. Adam P,
    5. Parolini C,
    6. Scarpa A, et al.
    Establishment of the MAVER-1 cell line, a model for leukemic and aggressive mantle cell lymphoma. Haematologica. 2006; 91: 40-7.
    OpenUrlAbstract/FREE Full Text
  31. 31.↵
    1. Roecklein BA,
    2. Torok-Storb B.
    Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes. Blood. 1995; 85: 997–1005.
    OpenUrlAbstract/FREE Full Text
  32. 32.↵
    1. Nakagawa R,
    2. Soh JW,
    3. Michie AM.
    Subversion of protein kinase C alpha signaling in hematopoietic progenitor cells results in the Generation of a B-cell chronic lymphocytic leukemia-like population in vivo. Cancer Res. 2006; 66: 527–34.
    OpenUrlAbstract/FREE Full Text
  33. 33.↵
    1. Byrd JC,
    2. Furman RR,
    3. Coutre SE,
    4. Flinn IW,
    5. Burger JA,
    6. Blum KA, et al.
    Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia. N Engl J Med. 2013; 369: 32–42.
    OpenUrlCrossRefPubMedWeb of Science
  34. 34.↵
    1. Baouz S,
    2. Jacquet E,
    3. Bernardi A,
    4. Parmeggiani A.
    The N-terminal moiety of CDC25(Mm), a GDP/GTP exchange factor of Ras proteins, controls the activity of the catalytic domain. Modulation by calmodulin and calpain. J Biol Chem. 1997; 272: 6671–6.
    OpenUrlAbstract/FREE Full Text
  35. 35.↵
    1. Iacovelli S,
    2. Hug E,
    3. Bennardo S,
    4. Bennardo S,
    5. Duehren-von Minden M,
    6. Gobessi S,
    7. Rinaldi A, et al.
    Two types of BCR interactions are positively selected during leukemia development in the Emu-TCLl transgenic mouse model of CLL. Blood. 2015;125: 1578–88.
    OpenUrlAbstract/FREE Full Text
  36. 36.↵
    1. Purroy N,
    2. Abrisqueta P,
    3. Carabia J,
    4. Carpio C,
    5. Palacio C,
    6. Bosch F, et al.
    Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo. Oncotarget. 2015; 6: 7632–43.
    OpenUrl
  37. 37.↵
    1. Etienne-Manneville S,
    2. Hall A.
    Rho GTPases in cell biology. Nature. 2002; 420:629–35.
    OpenUrlCrossRefPubMedWeb of Science
  38. 38.
    1. Huang C,
    2. Jacobson K,
    3. Schaller MD.
    MAP kinases and cell migration. J Cell Sci. 2004; 117: 4619–28.
    OpenUrlAbstract/FREE Full Text
  39. 39.↵
    1. Han MY,
    2. Kosako H,
    3. Watanabe T,
    4. Hattori S.
    Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN. Mol Cell Biol. 2007; 27: 8190–204.
    OpenUrlAbstract/FREE Full Text
  40. 40.↵
    1. Redondo-Muoz J,
    2. Escobar-Díaz E,
    3. Samaniego R,
    4. Terol MJ,
    5. García-Marco JA,
    6. García-Pardo A.
    MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood. 2006; 108: 3143–51.
    OpenUrlAbstract/FREE Full Text
  41. 41.↵
    1. Calpe E,
    2. Codony C,
    3. Baptista MJ,
    4. Abrisqueta P,
    5. Carpio C,
    6. Purroy N, et al.
    ZAP-70 enhances migration of malignant B lymphocytes toward CCL21 by inducing CCR7 expression via IgM-ERK1/2 activation. Blood. 2011; 118: 4401–10.
    OpenUrlAbstract/FREE Full Text
  42. 42.↵
    1. Richardson SJ,
    2. Matthews C,
    3. Catherwood MA,
    4. Alexander HD,
    5. Carey BS,
    6. Farrugia J, et al.
    ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL) Blood. 2006; 107: 3584-92.
    OpenUrlAbstract/FREE Full Text
  43. 43.↵
    1. Chen L,
    2. Widhopf G,
    3. Huynh L,
    4. Rassenti L,
    5. Rai KR,
    6. Weiss A, et al.
    Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood. 2002; 100: 4609-14.
    OpenUrlAbstract/FREE Full Text
  44. 44.
    1. Rassenti LZ,
    2. Jain S,
    3. Keating MJ,
    4. Wierda WG,
    5. Grever MR,
    6. Byrd JC, et al.
    Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia. Blood. 2008; 112: 1923–30.
    OpenUrlAbstract/FREE Full Text
  45. 45.↵
    1. Gobessi S,
    2. Laurenti L,
    3. Longo PG,
    4. Sica S,
    5. Leone G,
    6. Efremov DG.
    ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B-cells. Blood. 2007; 109: 2032–9.
    OpenUrlAbstract/FREE Full Text
PreviousNext
Back to top

In this issue

Cancer Biology and Medicine: 13 (2)
Cancer Biology & Medicine
Vol. 13, Issue 2
1 Jun 2016
  • Table of Contents
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Cancer Biology & Medicine.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies
(Your Name) has sent you a message from Cancer Biology & Medicine
(Your Name) thought you would like to see the Cancer Biology & Medicine web site.
Citation Tools
Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies
Wei Liao, Sanjai Sharma
Cancer Biology & Medicine Jun 2016, 13 (2) 277-285; DOI: 10.20892/j.issn.2095-3941.2016.0026

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Modulation of B-cell receptor and microenvironment signaling by a guanine exchange factor in B-cell malignancies
Wei Liao, Sanjai Sharma
Cancer Biology & Medicine Jun 2016, 13 (2) 277-285; DOI: 10.20892/j.issn.2095-3941.2016.0026
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • The Origin of Bladder Cancer from Mucosal Field Effects
  • Google Scholar

More in this TOC Section

  • VAMP2/SNAP25 promotes the aggressive progression of head and neck cancer by regulating the fate of multivesicular bodies
  • Lenvatinib triggers an EGR1-ZNF768-SLC7A11 adaptive response to limit ferroptosis-mediated therapeutic efficacy in hepatocellular carcinoma
  • Bifidobacterium animalis suppresses melanoma progression and activates anti-tumor immunity by inhibiting YAP1 expression in CD8+ T cells
Show more Original Article

Similar Articles

Keywords

  • B-cell malignancies
  • Mantle cell lymphoma
  • chronic lymphocytic leukemia (CLL)
  • B-cell receptor
  • guanine exchange factor
  • Rasgrf-1
  • ERK pathway

Navigate

  • Home
  • Current Issue

More Information

  • About CBM
  • About CACA
  • About TMUCIH
  • Editorial Board
  • Subscription

For Authors

  • Instructions for authors
  • Journal Policies
  • Submit a Manuscript

Journal Services

  • Email Alerts
  • Facebook
  • RSS Feeds
  • Twitter

 

© 2026 Cancer Biology & Medicine

Powered by HighWire