Review ArticleReview

Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients

Wen-Ya Zhou, Hong Zheng, Xiao-Ling Du and Ji-Long Yang
Cancer Biology & Medicine June 2016, 13 (2) 260-268; DOI: https://doi.org/10.20892/j.issn.2095-3941.2015.0102

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  • Table 1

    Ligand specificities of the FGFR family

    ReceptorLigand
    FGF1-1032FGFR15-23
    FGFR1FGFR-1bFGF-1, 2, 3, and 10FGF-1633, 1834, 2035, 2136, and 2337
    FGFR-1CFGF-1, 2, 4, 5, and 6
    FGFR2FGFR-2bFGF-1, 3, 7, and 10FGF-1633, 1834, 2136, and 2238
    FGFR-2CFGF-1, 2, 4, 6, and 9
    FGFR3FGFR-3bFGF-1 and 9FGF-1739, 1840, and 2136
    FGFR-3CFGF-1, 2, 4, 8, and 9
    FGFR4FGFR-4FGF-1, 2, 4, 6, 8, and 9FGF-1541, 1842, 1943, and 2337

    FGF-1-10 was adapted from reference 32. As FGF-11-14 were intracellular non-secretory factors, these are not shown

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