Article Figures & Data
Tables
Cell type The influence of VEGF on the cell Reference Dendritic cell Inhibit the differentiation of DC in the hematopoietic process 30 Influence the function and maturation of DC 29 Increase the mDC and pDC in lung 32 Enable DC to differentiate into endothelial-like cell 33 Enable DC to get an angiogenic property 34 Macrophage Prevent inflammation during bacterial infection 35 Mediate the infiltration of macrophage in the lung 36 T lymphocyte Cause thymic atrophy 37 Costimulate IFN-γ production, increase chemotaxis 38 Induce epithelial activation, neutrophil chemotaxis in OAD 39 Treg Promote the induction and maintenance of Treg in the tumor site 40 Chemotaxis for Treg 5 Tumor cell Increase the migration, cell mobility and invasiveness of tumor cells 41–43 Promote cancer stemness 44 VEGF, vascular endothelial growth factor; DC, dendritic cell; mDC, myeloid DC; pDC, plasmacytoid DC; OAD, obliterative airway disease.
Cell type Expression of VEGF receptors Reference Hematopoietic cell VEGFR-1 30 Dendritic cell VEGFR-3 28 Macrophage VEGFR-1, VEGFR-3 53–55 T lymphocyte VEGFR-1, VEGFR-2 38,56 Treg tumor cell VEGFR-2, NRP-1 40 VEGFR-1, VEGFR-2, NRP-1 57,58
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- Article
- Abstract
- Introduction
- Biology of VEGF
- Biology of VEGFRs
- Relationship between VEGF/VEGFR and DCs
- Relationship between VEGF/VEGFR and macrophages
- Relationship between VEGF/VEGFR and T cells
- VEGF can be secreted by tumor cells and further stimulate cancer stemness
- Conclusions
- Acknowledgements
- Footnotes
- References
- Figures & Data
- Info & Metrics
- References
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