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Review ArticleReview

Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors

Jennifer Kleponis, Richard Skelton and Lei Zheng
Cancer Biology & Medicine September 2015, 12 (3) 201-208; DOI: https://doi.org/10.7497/j.issn.2095-3941.2015.0046
Jennifer Kleponis
1Department of Oncology, Department of Surgery, The Sidney Kimmel Comprehensive Cancer, The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
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Richard Skelton
2Masters of Health Science Program in Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 21287, USA
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Lei Zheng
1Department of Oncology, Department of Surgery, The Sidney Kimmel Comprehensive Cancer, The Skip Viragh Center for Pancreatic Cancer Research and Clinical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
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  • For correspondence: lzheng6{at}jhmi.edu
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Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors
Jennifer Kleponis, Richard Skelton, Lei Zheng
Cancer Biology & Medicine Sep 2015, 12 (3) 201-208; DOI: 10.7497/j.issn.2095-3941.2015.0046

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Fueling the engine and releasing the break: combinational therapy of cancer vaccines and immune checkpoint inhibitors
Jennifer Kleponis, Richard Skelton, Lei Zheng
Cancer Biology & Medicine Sep 2015, 12 (3) 201-208; DOI: 10.7497/j.issn.2095-3941.2015.0046
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  • Article
    • Abstract
    • Introduction
    • Immune checkpoints and their clinical inhibitors
    • Immune checkpoint inhibitors function on T cells
    • Vaccines: fueling the TME with T Cells
    • Fueling the engine and releasing the break: combination therapy
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  • cytotoxic T-lymphocyte antigen-4 (CTLA-4)
  • programmed death-1 (PD-1)
  • programmed cell death ligand-1 (PD-L1)

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