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Review ArticleReview

Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints

Niki Karachaliou, Maria Gonzalez Cao, Cristina Teixidó, Santiago Viteri, Daniela Morales-Espinosa, Mariacarmela Santarpia and Rafael Rosell
Cancer Biology & Medicine June 2015, 12 (2) 79-86; DOI: https://doi.org/10.7497/j.issn.2095-3941.2015.0029
Niki Karachaliou
1Instituto Oncológico Dr Rosell, Quiron Dexeus University Hospital, Barcelona 08028, Spain
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Maria Gonzalez Cao
1Instituto Oncológico Dr Rosell, Quiron Dexeus University Hospital, Barcelona 08028, Spain
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Cristina Teixidó
2Pangaea Biotech, Barcelona 08028, Spain
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Santiago Viteri
1Instituto Oncológico Dr Rosell, Quiron Dexeus University Hospital, Barcelona 08028, Spain
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Daniela Morales-Espinosa
1Instituto Oncológico Dr Rosell, Quiron Dexeus University Hospital, Barcelona 08028, Spain
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Mariacarmela Santarpia
3Medical Oncology Unit, Human Pathology Department, University of Messina, Messina 98122, Italy
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Rafael Rosell
1Instituto Oncológico Dr Rosell, Quiron Dexeus University Hospital, Barcelona 08028, Spain
2Pangaea Biotech, Barcelona 08028, Spain
4Catalan Institute of Oncology, Hospital Germans Trias i Pujol, Badalona 08916, Spain
5Molecular Oncology Research (MORe) Foundation, Barcelona 08028, Spain
6Germans Trias i Pujol Health Sciences Institute and Hospital, Campus Can Ruti 08916, Spain
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  • For correspondence: rrosell{at}iconcologia.net
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Cancer Biology and Medicine: 12 (2)
Cancer Biology & Medicine
Vol. 12, Issue 2
1 Jun 2015
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Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints
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Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints
Niki Karachaliou, Maria Gonzalez Cao, Cristina Teixidó, Santiago Viteri, Daniela Morales-Espinosa, Mariacarmela Santarpia, Rafael Rosell
Cancer Biology & Medicine Jun 2015, 12 (2) 79-86; DOI: 10.7497/j.issn.2095-3941.2015.0029

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Understanding the function and dysfunction of the immune system in lung cancer: the role of immune checkpoints
Niki Karachaliou, Maria Gonzalez Cao, Cristina Teixidó, Santiago Viteri, Daniela Morales-Espinosa, Mariacarmela Santarpia, Rafael Rosell
Cancer Biology & Medicine Jun 2015, 12 (2) 79-86; DOI: 10.7497/j.issn.2095-3941.2015.0029
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  • Article
    • Abstract
    • Introduction
    • What is an immune checkpoint?
    • Immune response and cancer
    • Tumor and PD-L1 expression
    • Cancer immunotherapy in clinical practice
    • Biomarkers and response to immunotherapy; neoantigen load as a potential biomarker for cancer immunotherapy
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • References
  • PDF

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Keywords

  • Lung cancer
  • immunotherapy
  • immune checkpoint
  • program death-ligand 1 (PD-L1)
  • program death-1 (PD-1)

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