PD-L1 expression associated with better response to EGFR tyrosine kinase inhibitors

References

1. 1.↵
   2. Pardoll DM.

   The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252–264.

   OpenUrlCrossRefPubMedWeb of Science
2. 2.↵
   2. Schreiber RD,
   3. Old LJ,
   4. Smyth MJ.

   Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science 2011;331:1565–1570.

   OpenUrlAbstract/FREE Full Text
3. 3.↵
   2. Pao W,
   3. Girard N.

   New driver mutations in non-small-cell lung cancer. Lancet Oncol 2011;12:175–180.

   OpenUrlCrossRefPubMedWeb of Science
4. 4.↵
   2. Xu C,
   3. Fillmore CM,
   4. Koyama S,
   5. Wu H,
   6. Zhao Y,
   7. Chen Z, et al.

   Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell 2014;25:590–604.

   OpenUrlCrossRefPubMedWeb of Science
5. 5.↵
   2. Akbay EA,
   3. Koyama S,
   4. Carretero J,
   5. Altabef A,
   6. Tchaicha JH,
   7. Christensen CL, et al.

   Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov 2013;3:1355–1363.

   OpenUrlAbstract/FREE Full Text
6. 6.↵
   2. D’Incecco A,
   3. Andreozzi M,
   4. Ludovini V,
   5. Rossi E,
   6. Capodanno A,
   7. Landi L, et al.

   PD-1 and PD-L1 expression in molecularly selected non-small-cell lung cancer patients. Br J Cancer 2015;112:95–102.

   OpenUrlCrossRefPubMed
7. 7.↵
   2. Gettinger S,
   3. Horn L,
   4. Antonia SJ,
   5. Spigel DR,
   6. Gandhi L,
   7. Sequist LV, et al.

   Efficacy of nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients with previously treated advanced non-small cell lung cancer (NSCLC): subpopulation response analysis in a phase 1 trial. Thorac Oncol 2013;8:P2.11–038.

   OpenUrl
8. 8.↵
   2. Chen N,
   3. Fang W,
   4. Zhan J,
   5. Hong S,
   6. Tang Y,
   7. Kang S, et al.

   Up-regulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation. J Thorac Oncol 2015. [Epub ahead of print].
9. 9.↵
   2. Mu CY,
   3. Huang JA,
   4. Chen Y,
   5. Chen C,
   6. Zhang XG.

   High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol 2011;28:682–688.

   OpenUrlCrossRefPubMed
10. 10.↵
    2. Zhang Y,
    3. Wang L,
    4. Li Y,
    5. Pan Y,
    6. Wang R,
    7. Hu H, et al.

    Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma. Onco Targets Ther 2014;7:567–573.

    OpenUrlPubMed
11. 11.↵
    2. Ansen S,
    3. Schultheis AM,
    4. Hellmich M,
    5. Zander T,
    6. Brockmann M,
    7. Stoelben E, et al.

    PD-L1 expression and genotype in non-small cell lung cancer (NSCLC). J Clin Oncol 2014;32:abstr 7517.
12. 12.↵
    2. Rizvi NA,
    3. Hellmann MD,
    4. Snyder A,
    5. Kvistborg P,
    6. Makarov V,
    7. Havel JJ, et al.

    Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015;348:124–128.

    OpenUrlAbstract/FREE Full Text
13. 13.↵
    2. Yang CY,
    3. Lin MW,
    4. Chang YL,
    5. Wu CT,
    6. Yang PC.

    Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. Eur J Cancer 2014;50:1361–1369.

    OpenUrlCrossRefPubMed
14. 14.↵
    2. Velcheti V,
    3. Schalper KA,
    4. Carvajal DE,
    5. Anagnostou VK,
    6. Syrigos KN,
    7. Sznol M, et al.

    Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest 2014;94:107–116.

    OpenUrlCrossRefPubMedWeb of Science
15. 15.↵
    2. Herbst RS,
    3. Soria JC,
    4. Kowanetz M,
    5. Fine GD,
    6. Hamid O,
    7. Gordon MS, et al.

    Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 2014;515:563–567.

    OpenUrlCrossRefPubMedWeb of Science