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LetterLetter to the Editor

Eukaryotic cell encystation and cancer cell dormancy: is a greater devil veiled in the details of a lesser evil?

Abdul Mannan Baig, Naveed Ahmed Khan and Farhat Abbas
Cancer Biology & Medicine March 2015, 12 (1) 64-67; DOI: https://doi.org/10.7497/j.issn.2095-3941.2014.0028
Abdul Mannan Baig
1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 75300, Pakistan
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  • For correspondence: abdul.mannan{at}aku.edu
Naveed Ahmed Khan
1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 75300, Pakistan
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Farhat Abbas
1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 75300, Pakistan
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    Figure 1

    (A) Cyst of Acanthamoeba castellanii exhibiting double-walled structure; (B) Induced cancer stem cells in lung carcinoma. During maturation of these cells, mitochondria appeared to play a key role in wall development, as these organelles assumed a centripetal layout helping to delimit border.

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    Figure 2

    Studying the crosstalks of eukaryotic cells with immune cells and identification of cytokines and/or mediators can help us understand the induction mechanism of microenvironment factors like hypoxia in the causation of dormancy.

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    Figure 3

    Row of LNCaP (above) and PC3 (below). (A) Induction of dormancy by the same stimuli that provoke encystation in Eukaryotic cells; (B) Cancer cells undergoing dormancy; (C) Dormant state established; (D) Revival from dormancy, by the same stimuli that cause excystation in eukaryotic cells.

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Cancer Biology and Medicine: 12 (1)
Cancer Biology & Medicine
Vol. 12, Issue 1
1 Mar 2015
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Eukaryotic cell encystation and cancer cell dormancy: is a greater devil veiled in the details of a lesser evil?
Abdul Mannan Baig, Naveed Ahmed Khan, Farhat Abbas
Cancer Biology & Medicine Mar 2015, 12 (1) 64-67; DOI: 10.7497/j.issn.2095-3941.2014.0028

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Eukaryotic cell encystation and cancer cell dormancy: is a greater devil veiled in the details of a lesser evil?
Abdul Mannan Baig, Naveed Ahmed Khan, Farhat Abbas
Cancer Biology & Medicine Mar 2015, 12 (1) 64-67; DOI: 10.7497/j.issn.2095-3941.2014.0028
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  • Article
    • Abstract
    • Cancer cell dormancy and eukaryotic cell encystation
    • MOTHER features homology that can facilitate the understanding of cancer cell dormancy
    • Signaling and crosstalk of cancers in the establishment of tumor dormancy
    • Acknowledgements
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    • References
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Keywords

  • Cancer cell dormancy
  • cancer recurrence
  • encystation
  • metastasis

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