Research ArticleOriginal Article

Effect of flupirtine on the growth and viability of U373 malignant glioma cells

Elango Panchanathan, Gnanasambandan Ramanathan and Bhaskar Venkata Kameswara Subrahmanya Lakkakula
Cancer Biology & Medicine September 2013, 10 (3) 142-147; DOI: https://doi.org/10.7497/j.issn.2095-3941.2013.03.004

References

  1. 1.↵
    2. Obermeier K,
    3. Niebch G,
    4. Thiemer K.
    Pharmacokinetics and biotransformation of the analgesic flupirtine in the rat and dog. Arzneimittelforschung 1985;35:60–67.
    OpenUrlPubMed
  2. 2.↵
    2. Hlavica P,
    3. Niebch G.
    Pharmacokinetics and biotransformation of the analgesic flupirtine in humans. Arzneimittelforschung 1985;35:67–74.
    OpenUrlPubMed
  3. 3.↵
    2. Li C,
    3. Ni J,
    4. Wang Z,
    5. Li M,
    6. Gasparic M,
    7. Terhaag B, et al.
    Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial. Curr Med Res Opin 2008;24:3523–3530.
    OpenUrl
  4. 4.↵
    2. Harish S,
    3. Bhuvana K,
    4. Bengalorkar GM,
    5. Kumar T.
    Flupirtine: Clinical pharmacology. J Anaesthesiol Clin Pharmacol 2012;28:172–177.
    OpenUrlCrossRefPubMed
  5. 5.↵
    2. Otto M,
    3. Cepek L,
    4. Ratzka P,
    5. Doehlinger S,
    6. Boekhoff I,
    7. Wiltfang J, et al.
    Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study. Neurology 2004;62:714–718.
    OpenUrlCrossRefPubMed
  6. 6.↵
    2. Kornhuber J,
    3. Bleich S,
    4. Wiltfang J,
    5. Maler M,
    6. Parsons CG.
    Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication. J Neural Transm 1999;106:857–867.
    OpenUrl
  7. 7.↵
    2. Szelenyi I,
    3. Nickel B,
    4. Borbe HO,
    5. Brune K.
    Mode of antinociceptive action of flupirtine in the rat. Br J Pharmacol 1989;97:835–842.
    OpenUrl
  8. 8.↵
    2. Klinger F,
    3. Geier P,
    4. Dorostkar MM,
    5. Chandaka GK,
    6. Yousuf A,
    7. Salzer I, et al.
    Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol 2012;166:1631–1642.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    2. Block F,
    3. Schwarz M,
    4. Sontag KH.
    Retinal ischemia induced by occlusion of both common carotid arteries in rats as demonstrated by electroretinography. Neurosci Lett 1992;144:124–126.
    OpenUrlCrossRefPubMedWeb of Science
  10. 10.↵
    2. Rupalla K,
    3. Cao W,
    4. Krieglstein J.
    Flupirtine protects neurons against excitotoxic or ischemic damage and inhibits the increase in cytosolic Ca2+ concentration. Eur J Pharmacol 1995;294:469–473.
    OpenUrlCrossRefPubMed
  11. 11.↵
    2. Ceruti S,
    3. Franceschi C,
    4. Barbieri D,
    5. Malorni W,
    6. Camurri A,
    7. Giammarioli AM, et al.
    Apoptosis induced by 2-chloro-adenosine and 2-chloro-2’-deoxy-adenosine in a human astrocytoma cell line: differential mechanisms and possible clinical relevance. J Neurosci Res 2000;60:388–400.
    OpenUrlCrossRefPubMedWeb of Science
  12. 12.↵
    2. Scheef W,
    3. Wolf-Gruber D.
    Flupirtine in patients with cancer pain. Arzneimittelforschung 1985;35:75–77.
    OpenUrlPubMed
  13. 13.↵
    2. Scheef W.
    Analgesic efficacy and safety of oral flupirtine in the treatment of cancer pain. Postgrad Med J 1987;63 Suppl 3:67–70.
    OpenUrlFREE Full Text
  14. 14.↵
    2. Goodchild CS,
    3. Nelson J,
    4. Cooke I,
    5. Ashby M,
    6. Jackson K.
    Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer. Pain Med 2008;9:939–949.
    OpenUrl
  15. 15.↵
    2. Perovic S,
    3. Schröder HC,
    4. Pergande G,
    5. Ushijima H,
    6. Müller WE.
    Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126). Exp Neurol 1997;147:518–524.
    OpenUrlCrossRefPubMed
  16. 16.↵
    2. Perovic S,
    3. Böhm M,
    4. Meesters E,
    5. Meinhardt A,
    6. Pergande G,
    7. Müller WE.
    Pharmacological intervention in age-associated brain disorders by Flupirtine: Alzheimer’s and prion diseases. Mech Ageing Dev 1998;101:1–19.
    OpenUrlCrossRefPubMed
  17. 17.↵
    2. Müller WE,
    3. Romero FJ,
    4. Perovic S,
    5. Pergande G,
    6. Pialoglou P.
    Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion. J Neurochem 1997;68:2371–2377.
    OpenUrlPubMedWeb of Science
  18. 18.↵
    2. Osborne NN,
    3. Schwarz M,
    4. Pergande G.
    Protection of rabbit retina from ischemic injury by flupirtine. Invest Ophthalmol Vis Sci 1996;37:274–280.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    2. Sättler MB,
    3. Williams SK,
    4. Neusch C,
    5. Otto M,
    6. Pehlke JR,
    7. Bähr M, et al.
    Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. Am J Pathol 2008;173:1496–1507.
    OpenUrlCrossRefPubMed
  20. 20.↵
    2. Boscia F,
    3. Annunziato L,
    4. Taglialatela M.
    Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures. Neuropharmacology 2006;51:283–294.
    OpenUrlCrossRefPubMedWeb of Science
  21. 21.↵
    2. Galasko CS,
    3. Courtenay PM,
    4. Jane M,
    5. Stamp TC.
    Trial of oral flupirtine maleate in the treatment of pain after orthopaedic surgery. Curr Med Res Opin 1985;9:594–601.
    OpenUrlCrossRefPubMed
  22. 22.↵
    2. Heusinger JH.
    Efficacy and tolerance of flupirtine and pentazocine in two multicentre trials. Postgrad Med J 1987;63 Suppl 3:71–79.
    OpenUrlFREE Full Text
  23. 23.↵
    2. Lüben V,
    3. Müller H,
    4. Lobisch M,
    5. Wörz R.
    Treatment of tumor pain with flupirtine. Results of a double-blind study versus tramadol. Fortschr Med 1994;112:282–286.
    OpenUrlPubMed
  24. 24.↵
    2. Million R,
    3. Finlay BR,
    4. Whittington JR.
    Clinical trial of flupirtine maleate in patients with migraine. Curr Med Res Opin 1984;9:204–212.
    OpenUrlCrossRefPubMed
  25. 25.↵
    2. Nickel B,
    3. Zerrahn H.
    Pharmaco-electroencephalography in the rat as a method for characterization of different types of analgesics. Postgrad Med J 1987;63 Suppl 3:45–47.
    OpenUrlAbstract/FREE Full Text
  26. 26.↵
    2. Mastronardi P,
    3. D’Onofrio M,
    4. Scanni E,
    5. Pinto M,
    6. Frontespezi S,
    7. Ceccarelli MG, et al.
    Analgesic activity of flupirtine maleate: a controlled double-blind study with diclofenac sodium in orthopaedics. J Int Med Res 1988;16:338–348.
    OpenUrlCrossRefPubMed
  27. 27.↵
    2. Raffa RB,
    3. Pergolizzi JV Jr..
    The evolving understanding of the analgesic mechanism of action of flupirtine. J Clin Pharm Ther 2012;37:4–6.
    OpenUrlPubMed
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools

Jump to section

Keywords