Article Figures & Data
Figures
- Figure 1
Number of chemotherapeutic cycles recorded in 445 patients.
- Figure 2
Kaplan-Meier survival curves of the three groups of leucopenia.
Tables
- Table 1.
Baseline demographics and clinical characteristics in patients and in subgroups based on the grade of leukopenia
Characteristics All patients n=445 Leukopenia (grade 0-4) P 0 1 2 3 4 Age, years 59 (18-80) 57 (30-78) 60 (18-78) 58 (35-80) 59 (28-81) 62 (40-79) 0.063 Gender 0.042 Male 340 62 53 80 86 59 Female 105 10 14 35 24 22 Performance Score 0.04 0 345 61 52 97 86 59 1 81 9 14 16 18 14 2 19 2 1 2 6 8 Stage 0.022 Limited 233 48 35 62 56 32 Extensive 212 24 32 53 54 49 Pathology 0.094 Small-cell 368 55 56 100 85 72 Mixed small-cell 77 17 11 15 25 9 Tumor location 0.739 Central 247 38 36 68 57 48 Peripheral 198 34 31 47 53 33 Radiotherapy History 0.189 Yes 220 32 34 66 55 33 No 225 40 33 49 55 48 Chemotherapy cycles 0.001 <6 195 49 35 46 34 31 ≥6 250 23 32 69 76 50 - Table 2.
Multivariate Cox model for the association between survival and chemotherapy-induced leukopenia
Characteristics Hazard ratio (95% CI) P Leukopenia 0.002 Mild vs. absence 0.687 (0.506-0.943) 0.017 Severe vs. mild 1.414 (1.147-1.744) 0.001 Severe vs. absence 0.901 (0.669-1.214) 0.494 Gender Male vs. female 1.335 (1.042-1.709) 0.022 PS status 2 vs. 0-1 1.591 (1.274-1.988) <0.001 Stage Extensive vs. limited 1.959 (1.589-2.416) <0.001 Thoracic radiotherapy Yes vs. no 0.806 (0.649-0.996) 0.046 PCI history Yes vs. no 0.591 (0.379-0.920) 0.020
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