Clinical Analysis of Diagnosis and Treatment of Gastrointestinal Stromal Tumors (Report of 96 Cases)

OBJECTIVE To investigate the pathological diagnosis, surgical treatment and prognosis of gastrointestinal stromal tumors (GIST).

METHODS The clinicopathologlcal data of 96 post-operative cases with GIST were analyzed retrospectively, and expression of immunohistochemical staining of CD117, CD34, SMA and S-100 was determined.

RESULTS Immunohistochemical positive staining showed: CD117, 79.1% (76/96); CD34, 58.3% (56/96); SMA, 35.4% (34/96); S-100, 9.3% (9/96). Twenty-three benign cases and 73 malignant cases were reported. The omentums were resected in 39 malignant cases. For the other 34 malignant cases the omentums were left intact. The recurrent and metastatic rates were 5.1 % and 26.5%(P<0.05). The Incisal section between the normal bowel and the tumor was >5cm In 46 cases, for the other 27 cases, the section was < 5cm. The recurrent and metastatic rates were 6.5% and 29.6% (P <0.05), respectively. The 5-year survival rates of benign and malignant GIST were 91.5% and 57.3%(P<0.05).

CONCLUSION GIST were the most freuquent mesenchymal tumor seen In the gastrointestinal tract. The application of immunohistochemical markers CD117and CD34 are mutually beneficial for a final correct pathological diagnosis. The adaptation of a primary rational treatment, Including the complete tumor resection and preventive omentectomy could reduce the recurrence of GIST.