Objective: Abnormal metabolism is the underlying reason for breast cancer progression.
Decreased lactate dehydrogenase B (LDHB) has been detected in breast cancer but the …

Accelerated glycolysis leads to secretion and accumulation of lactate and protons in the
tumor environment and determines the efficacy of adoptive T cell and checkpoint inhibition …

Previous studies show that LDH-A knockdown reduces orthotopic 4T1 breast tumor lactate
and delays tumor growth and the development of metastases in nude mice. Here, we report …

Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis
and enhanced expression/activity of this enzyme has been correlated with poor prognosis …

Purpose: Although breast cancers are known to be molecularly heterogeneous, their
metabolic heterogeneity is less well understood. This study aimed to identify and evaluate …

Purpose: To investigate the relationship between lactate dehydrogenase A (LDH-A)
expression, lactate concentration, cell metabolism, and metastases in murine 4T1 breast …

Lactate dehydrogenase B (LDHB) is widely expressed in adult somatic tissue and is one of
the two subunits of lactate dehydrogenase, which is the key glycolytic enzyme and catalyzes …

Lactate dehydrogenase (LDH) is being increasingly recognized as a major factor in the
progression of breast cancer. It was previously shown that short interfering RNA‑mediated …

Background Head and neck squamous cell carcinoma (HNSCC) is one of the most common
malignancies. Lactate dehydrogenase family genes (LDHs) play a critical role in tumor …

Breast cancer has been redefined into three clinically relevant subclasses:(i)
estrogen/progesterone receptor positive (ER+/PR+),(ii) HER2/ERRB2 positive, and (iii) …