[HTML][HTML] BLM helicase inhibition synergizes with PARP inhibition to improve the radiosensitivity of olaparib resistant non-small cell lung cancer cells by inhibiting …
Y Kong, C Xu, X Sun, H Sun, X Zhao, N He… - Cancer biology & …, 2022 - ncbi.nlm.nih.gov
Objective: We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose
polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase …
polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase …
p38 MAPK inhibitor SB203580 enhances anticancer activity of PARP inhibitor olaparib in a synergistic way on non-small cell lung carcinoma A549 cells
P Dey, S Biswas, R Das, S Chatterjee… - … and Biophysical Research …, 2023 - Elsevier
The Poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) olaparib gives promising
results against various types of cancers in clinical trials. The combination of drugs always …
results against various types of cancers in clinical trials. The combination of drugs always …
Inhibition of Parp1 by BMN673 effectively sensitizes cells to radiotherapy by upsetting the balance of repair pathways processing DNA double-strand breaks
A Soni, F Li, Y Wang, M Grabos, LM Krieger… - Molecular cancer …, 2018 - AACR
Parp inhibitors (Parpi) are commonly used as single agents for the management of tumors
with homologous recombination repair (HRR) deficiencies, but combination with …
with homologous recombination repair (HRR) deficiencies, but combination with …
[HTML][HTML] PARP1 inhibition radiosensitizes HNSCC cells deficient in homologous recombination by disabling the DNA replication fork elongation response
S Wurster, F Hennes, AC Parplys, JI Seelbach… - Oncotarget, 2016 - ncbi.nlm.nih.gov
There is a need to develop new, more efficient therapies for head and neck cancer (HNSCC)
patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' …
patients. It is currently unclear whether defects in DNA repair genes play a role in HNSCCs' …
Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft
JM Senra, BA Telfer, KE Cherry, CM McCrudden… - Molecular cancer …, 2011 - AACR
PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1
increases the effectiveness of radiation in killing tumor cells. However, although the …
increases the effectiveness of radiation in killing tumor cells. However, although the …
Non-small cell lung cancer cells with deficiencies in homologous recombination genes are sensitive to PARP inhibitors
W Ji, X Weng, D Xu, S Cai, H Lou, L Ding - Biochemical and biophysical …, 2020 - Elsevier
Lung cancer is the leading cause of cancer death worldwide. PARP inhibitors have become
a new line of cancer therapy and a successful demonstration of the synthetic lethality …
a new line of cancer therapy and a successful demonstration of the synthetic lethality …
BMN673 is a PARP inhibitor with unique radiosensitizing properties: mechanisms and potential in radiation therapy
A Soni, X Lin, E Mladenov, V Mladenova, M Stuschke… - Cancers, 2022 - mdpi.com
Simple Summary PARP inhibitors (PARPi) have broad applicability as monotherapy in
tumors with HR defects. However, their combination with radiotherapy (RT) is less advanced …
tumors with HR defects. However, their combination with radiotherapy (RT) is less advanced …
Effect and mechanism of radiosensitization of poly (ADP-Ribose) polymerase inhibitor on lewis cells and xenografts
W Wei, D Bixia, Z Li - Zhongguo Fei Ai Za Zhi, 2016 - search.proquest.com
背景与目的 受电离辐射的肿瘤细胞 DNA 损伤主要为单链断裂 (single strand break, SSB)
与双链断裂 (double strand break, DSB), 其中 SSBs 发生的频率数十倍于 DSBs, 而 SSBs …
与双链断裂 (double strand break, DSB), 其中 SSBs 发生的频率数十倍于 DSBs, 而 SSBs …
Fluzoparib increases radiation sensitivity of non-small cell lung cancer (NSCLC) cells without BRCA1/2 mutation, a novel PARP1 inhibitor undergoing clinical trials
J Luo, X Dai, H Hu, J Chen, L Zhao, C Yang… - Journal of cancer …, 2020 - Springer
Propose Poly (ADP-ribose) polymerase 1 inhibitors were originally investigated as anti-
cancer therapeutics with BRCA1/2 genes mutation. Here, we investigate the effectiveness of …
cancer therapeutics with BRCA1/2 genes mutation. Here, we investigate the effectiveness of …
[HTML][HTML] Inhibition of PARP1-dependent end-joining contributes to Olaparib-mediated radiosensitization in tumor cells
A Kötter, K Cornils, K Borgmann, J Dahm-Daphi… - Molecular …, 2014 - Elsevier
Poly-ADP-ribose-polymerase inhibitors (PARPi) are considered to be optimal tools for
specifically enhancing radiosensitivity. This effect has been shown to be replication …
specifically enhancing radiosensitivity. This effect has been shown to be replication …
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