Objective This study was conducted to investigate ATP-induced growth inhibition in human
leukemic cells KG1a. Methods ATP inhibited cell growth was analyzed by MTS assay …

The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However,
recent evidence suggests a role for P2X7 in cell proliferation. Here, we found that P2X7 …

The occurrence and development of tumors is a multi-factor, multi-step, multi-gene
pathological process, and its treatment has been the most difficult problem in the field of …

Previous studies have demonstrated that activation of P2X 7 receptors (P2X 7 R) results in
the proliferation and migration of some types of tumor. Here, we asked whether and how the …

Objective To explore the role of P2X7 receptor (P2X7R) in migration and invasion of mouse
Lewis lung cancer (LLC) cells and examine the tumorigenic ability of LLC cells in P2X7R …

Objective To clone the entire coding sequence and analyze the function of P2X7 receptor of
J6-1 human leukemia cells. Methods The entire coding sequence of P2X7 receptor was …

Objective To investigate the expression of P2X7 receptor (P2X7R) and the effect of P2X7R
agonist 2'-3'-O-(4-benzoyl-benzoyl) ethane adenosine triphosphate three amine salt …

ABSTRACT P2X7 receptor is an ion channel receptor with adenosine triphosphate (ATP) as
its ligand, which is widely expressed in various immune cells and tissues. Activated P2X7 …

Background Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with
the worst survival rates and least effective treatments. Moreover, total deaths due to PDAC …

Extracellular ATP accumulated in tumor microenvironment activates P2X7 receptor on
cellular membrane of cancer cells. Recently, an importance of P2X7 receptor in cancer …