Objective: Immature vasculature lacking pericyte coverage substantially contributes to tumor
growth, drug resistance, and cancer cell dissemination. We previously demonstrated that …

Persistent inflammation and neovascularization are critical to cancer development. In
addition to upregulation of positive control mechanisms such as overexpression of …

Lymphatic metastasis is facilitated by lymphangiogenic growth factor vascular endothelial
growth factor‐C (VEGFC) that is secreted by some primary tumors. We previously identified …

Macrophages of the M2 phenotype in malignant tumors significantly aid tumor progression
and metastasis, as opposed to the M1 phenotype that exhibits anti-cancer characteristics …

Endothelial cells in an established vasculature secrete tumor necrosis factor superfamily-15
(TNFSF15; VEGI; TL1A) that functions as a negative modulator of neovascularization to …

Tumor growth relies on the formation of new blood vessels to receive an adequate supply of
oxygen and nutrient. This process is facilitated by both the remodeling of the pre-existing …

Improving tumor perfusion, thus tempering tumor-associated hypoxia, is known to impair
cancer progression. Previous work from our laboratory has shown that VEGF-A165 and …

Background New blood vessel formation, or angiogenic switch, is an essential event in the
development of solid tumors and their metastatic growth. Tumor blood vessel formation and …

Tumor-associated myeloid cells are believed to promote tumor development by stimulating
tumor growth, angiogenesis, invasion, and metastasis. Tumor-associated myeloid cells that …

Vascular hyperpermeability occurs in angiogenesis and several pathobiological conditions,
producing elevated interstitial fluid pressure and lymphangiogenesis. How these closely …