The COP9 signalosome (CSN) is a highly conserved protein complex composed of 8
subunits (CSN1 to CSN8). The individual subunits of the CSN play essential roles in cell …

The COP9 signalosome (CSN) is a central component of the activation and remodelling
cycle of cullin-RING E3 ubiquitin ligases (CRLs), the largest enzyme family of the ubiquitin …

In the last several years, multiple lines of evidence have suggested that the COP9
signalosome (CSN) plays a significant role in the regulation of multiple cancers and could …

The constitutive photomorphogenesis 9 signalosome (COP9 or CSN) is an evolutionarily
conserved multiprotein complex found in plants and animals. Because of the homology …

The COP9 signalosome (CSN) is a platform for protein communication in eukaryotic cells. It
has an intrinsic metalloprotease that removes the ubiquitin (Ub)-like protein Nedd8 from …

CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN),
which is an evolutionarily conserved multiprotein complex found in plants and animals and …

Recently the COP9 signalosome (CSN) has become a focus of interest for many
researchers, because of its function at the interface between signal transduction and …

COPS3 encodes the third subunit of the COP9 signalosome and its aberrant expression is
associated with many RITE (“Region of Increased Tumor Expression”) genes in lung cancer …

The eight subunits containing COP9 signalosome (CSN) complex, is highly conserved
among eukaryotes. CSN, identified as a negative regulator of photomorphogenesis, has …

The COP9 signalosome (CSN)–cullin-RING ubiquitin (Ub)-ligase (CRL) pathway is a
prominent segment of the Ub proteasome system (UPS). It specifically ubiquitinates proteins …