Despite major improvements in cancer survival, metastasis is responsible for almost 90% of
cancer-related mortality 1, 2. Nonetheless, the pathogenesis and molecular mechanisms of …

Cancer metastasis refers to the sequence of events whereby tumour cells detach from their
primary tissue, invade and migrate to nearby vasculature, intravasate into circulation, survive …

As highly conserved among diverse species, Hippo signaling pathway regulates various
biological processes, including development, cell proliferation, stem cell function, tissue …

Metastasis is an important cause of death from malignant tumors. It is of great significance to
explore the molecular mechanism of metastasis for the development of anti-cancer drugs …

Abstract Background The Hippo pathway is widely considered to inhibit cell growth and play
an important role in regulating the size of organs. However, recent studies have shown that …

The Hippo pathway is pervasively activated and has been well recognized to play critical
roles in human cancer. The deregulation of Hippo signaling involved in cancer …

The Hippo signaling is a highly conserved pathway that plays important roles in
tumorigenesis, stem cell self-renewal and differentiation, organ size control, and many other …

The Hippo pathway has generated considerable interest in recent years because of its
involvement in several key hallmarks of cancer progression and metastasis. Research on …

The Hippo signalling pathway monitors cell–cell contact and external factors that shape
tissue structure. In mice, tumourigenesis and developmental abnormalities are common …

The Hippo pathway regulates cancer biology in many aspects and the crosstalk with other
pathways complicates its role. Accumulated evidence has shown that the bidirectional …