[HTML][HTML] Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies
S Li, T Wang, X Xiao, X Zheng, H Sun… - Cancer Biology & …, 2024 - ncbi.nlm.nih.gov
Objective: The human cluster of differentiation (CD) 300A, a type-I transmembrane protein
with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential …
with immunoreceptor tyrosine-based inhibitory motifs, was investigated as a potential …
CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia
Upregulation of the immunosuppressive cell surface glycoprotein, CD200, is a common
feature of acute myeloid leukemia (AML) and is associated with poor patient outcome. We …
feature of acute myeloid leukemia (AML) and is associated with poor patient outcome. We …
[HTML][HTML] CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis
HJ Morgan, E Rees, S Lanfredini… - The Journal of …, 2022 - Am Soc Clin Investig
The basis of immune evasion, a hallmark of cancer, can differ even when cancers arise from
one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell …
one cell type such as in the human skin keratinocyte carcinomas: basal and squamous cell …
[HTML][HTML] Engagement of CD300c by a novel monoclonal antibody induces the differentiation of monocytes to M1 macrophages
SI Lee, H Kim, CK Lim, JD Kim, JS Heo, J Jung, C Kim… - Immunobiology, 2024 - Elsevier
Human CD300c is expressed on various immune or cancer cells and is a novel B7 family
member, functioning as an activity modulator on immune cells. To elucidate the function of …
member, functioning as an activity modulator on immune cells. To elucidate the function of …
Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy
CD96 has recently been shown as a negative regulator of mouse natural killer (NK)–cell
activity, with Cd96−/− mice displaying hyperresponsive NK cells upon immune challenge. In …
activity, with Cd96−/− mice displaying hyperresponsive NK cells upon immune challenge. In …
[PDF][PDF] CD200 suppresses the natural killer cells and decreased its activity in acute myeloid leukemia patients
M Atfy, HF Ebian, SM Elshorbagy, HH Atteia - J Leukemia, 2015 - researchgate.net
Immunosuppression is greatly involved in tumor escape from immune surveillance in acute
myeloid leukemia (AML) patients. Being an immunosuppressive molecule, CD200 is …
myeloid leukemia (AML) patients. Being an immunosuppressive molecule, CD200 is …
The interaction between CD 300a and phosphatidylserine inhibits tumor cell killing by NK cells
The activity of NK cells is controlled by inhibitory and activating receptors. The inhibitory
receptors interact mostly with MHC class I proteins, however, inhibitory receptors such as …
receptors interact mostly with MHC class I proteins, however, inhibitory receptors such as …
Protein kinase D3 promotes the reconstruction of OSCC immune escape niche Via regulating MHC-I and immune inhibit molecules expression
D Lv, J Chen, Y Kang, M Luo, H Chen… - Journal of …, 2021 - journals.lww.com
Abstract Protein kinase D3 (PKD3) has been involved in various aspects of tumorigenesis
and progression in many kinds of cancer types. However, whether PKD3 regulates immune …
and progression in many kinds of cancer types. However, whether PKD3 regulates immune …
The CD200–CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K
Abstract The CD200–CD200R immunoregulatory signaling axis plays an etiologic role in the
survival and spread of numerous cancers, primarily through suppression of antitumor …
survival and spread of numerous cancers, primarily through suppression of antitumor …
Protein kinase C delta regulates mononuclear phagocytes and hinders response to immunotherapy in cancer
Mononuclear phagocytes (MPs) play a crucial role in tissue homeostasis; however, MPs
also contribute to tumor progression and resistance to immune checkpoint blockade (ICB) …
also contribute to tumor progression and resistance to immune checkpoint blockade (ICB) …
