Oncolytic virotherapy has emerged as a promising treatment for human cancers owing to an
ability to elicit curative effects via systemic administration. Tumor cells often create an …

Oncolytic virotherapy (OVT) is a promising form of cancer treatment that uses genetically
engineered viruses to replicate within cancer cells and trigger anti-tumor immune response …

The use of genetically engineered, tumor-targeting viruses as oncolytic agents has recently
emerged as a promising new area for the development of novel cancer therapies. The first …

The use of oncolytic viruses for the treatment of cancer is an emerging field of cancer
research and therapy. Oncolytic viruses are designed to induce tumor specific immunity …

Introduction Immunotherapy is a rapidly evolving area of cancer therapeutics aimed at
driving a systemic immune response to fight cancer. Oncolytic viruses (OVs) are at the …

Cancer vaccines and oncolytic immunotherapy are promising treatment strategies with
potential to provide greater clinical benefit to patients with advanced-stage cancer. In …

Vaccinia virus (VV) has emerged as a promising platform for oncolytic virotherapy. Many
clinical VV candidates, such as the double-deleted VV, vvDD, are engineered with deletions …

The concept of oncolytic viral therapy was based on the hypothesis that engineering tumor-
selectivity into the replication potential of viruses would permit direct destruction of tumor …

Background Vaccinia virus was widely used in the World Health Organization's smallpox
eradication campaign and is currently a promising vector for gene therapy owing to its …

While cure rates for several cancers have significantly improved, the outcome for patients
with advanced solid tumors remains grimly unchanged over the last decades. Thus, there is …