The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is
characterized by predisposition to cancer. Patients with AT have an elevated risk of breast …

Mutations in the ATM gene are the cause of a rare autosomal recessive syndrome, ataxia-
telangiectasia (AT). Of the general population,≈ 0.35-1% has been estimated to be …

The ATM kinase has an essential role in maintaining genomic integrity. Loss of both ATM
alleles results in ataxia‐telangiectasia (A‐T), a rare autosomal recessive neuroimmunologic …

Mutations in ATM are responsible for the autosomal recessive disorder ataxia telangiectasia.
Heterozygous mutations in ATM have been associated with an elevated risk of breast …

Abstract Purpose The Ataxia-telangiectasia mutated (ATM) gene encodes a multifunctional
kinase, which is linked to important cellular functions. Women heterozygous for ATM …

Heterozygosity for ataxia-telangiectasia (AT), a cancer-prone recessive syndrome, has been
associated with an increased risk of breast cancer. The gene for AT (ATM) is located at …

The failure to find an increased frequency of ATM mutations in large cancer cohorts,
especially breast cancer, is contrary to what was anticipated based on the increased cancer …

Ataxia-telangiectasia (AT) is a multisystem recessive disease characterized clinically by
cerebellar ataxia, oculocutaneous telangiectasias, immunodeficiency, sensitivity to …

The human genetic disorder ataxia-telangiectasia (AT) is characterized by hypersensitivity to
ionizing radiation and an elevated risk of malignancy. Epidemiological data support an …

Homozygous mutation in the ATM gene causes ataxia telangiectasia and heterozygous
mutation carriers may be at increased risk of breast cancer. We studied a total of 22 ATM …