DNA methylation, a reversible post-replication modification, defines gene expression and
function in different physiologic processes. Hypomethylation is quite common among global …

DNA methylation, the addition of a methyl group to the carbon-5 position of cytosine
residues, is the only common covalent modification of human DNA and occurs almost …

The importanceofestablishingand maintaining properDNA methylation patterns is mostdra-
maticallyhighlighted by disturbances causingor contributingtohumandiseases. Mutations in …

Methylation of DNA is known to be an important mechanism of gene regulation. A hallmark
of cancer is the deregulation of the DNA methylation machinery and aberrant DNA …

In eukaryotes, the epigenetic mark DNA methylation is found exclusively at cytosine
residues in the CpG islands of genes, transposons and intergenic DNA. Among functional …

Alterations of DNA methylation are one of the most consistent epigenetic changes in human
cancers. Human cancers generally show global DNA hypomethylation accompanied by …

The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled
through the interdigitation of DNA binding proteins such as histones and their modifiers, the …

Human malignant tumors are characterized by pervasive changes in the patterns of DNA
methylation. These changes include a globally hypomethylated tumor cell genome and the …

There is overwhelming evidence that DNA methylation patterns are altered in cancer.
Methylation of CG-rich islands in regulatory regions of genes marks them for transcriptional …

Recent conceptual advances in the field of DNA methylation and the advent and rapid
development of new technologies in epigenomics have started to unravel the mechanisms …