Objective: This study aimed to evaluate the effects of mitochondrial pyruvate carrier (MPC)
blockade on the sensitivity of detection and radiotherapy of prostate cancer (PCa). Methods …

Aerobic glycolysis is one of the important hallmarks of cancer cells and eukaryotic cells. In
this study, we have investigated the relationship between blocking mitochondrial pyruvate …

One of the remarkable features of cancer cells is aerobic glycolysis, a phenomenon known
as the “Warburg Effect”, in which cells rely preferentially on glycolysis instead of oxidative …

Specific metabolic underpinnings of androgen receptor (AR)-driven growth in prostate
adenocarcinoma (PCa) are largely undefined, hindering the development of strategies to …

Simple Summary The characteristic metabolic hallmark of cancer cells is the massive
catabolism of glucose by glycolysis, even under aerobic conditions—the so-called Warburg …

Background Most cancer cells are more glycolytic even under aerobic conditions compared
with their normal counterparts. Recent evidence of tumor cell metabolism, however, shows …

New data published in Nature Metabolism show that the androgen receptor (AR)
transcriptionally regulates the mitochondrial pyruvate carrier (MPC). Inhibition of the MPC in …

Aims Pyruvate carboxylase (PC) plays a key role in cancer cell metabolic reprogramming.
Whether metabolic reprogramming and PC are related in PDAC is unclear. Here, the effect …

Abstract Mitochondrial pyruvate carrier 1 (MPC1) and MPC 2 form a transporter complex in
cells to control pyruvate transportation into mitochondria. Reduced expression of MPC1 …

Abstract Mitochondrial pyruvate carrier 1 (MPC1) is a key metabolic protein that regulates
the transport of pyruvate into the mitochondrial inner membrane. MPC1 deficiency may …