[HTML][HTML] Understanding the mechanisms underlying obesity in remodeling the breast tumor immune microenvironment: from the perspective of inflammation

H Zhang, M Wang, Y Xu - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
Obesity is a well-known modifiable risk factor for breast cancer and is considered a poor
prognostic factor in pre-and post-menopausal women. While the systemic effects of obesity …

[HTML][HTML] The obesity-breast cancer link: a multidisciplinary perspective

EN Devericks, MS Carson, LE McCullough… - Cancer and Metastasis …, 2022 - Springer
Obesity, exceptionally prevalent in the USA, promotes the incidence and progression of
numerous cancer types including breast cancer. Complex, interacting metabolic and …

[HTML][HTML] Adipose tissue-to-breast cancer crosstalk: Comprehensive insights

Y Wu, X Li, Q Li, C Cheng, L Zheng - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
The review focuses on mechanistic evidence for the link between obesity and breast cancer.
According to the IARC study, there is sufficient evidence that obesity is closely related to a …

Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression

CA Gilbert, JM Slingerland - Annual review of medicine, 2013 - annualreviews.org
Obesity is a problem of epidemic proportions in many developed nations. Increased body
mass index and obesity are associated with a significantly worse outcome for many cancers …

[HTML][HTML] Obesity and cancer mechanisms: tumor microenvironment and inflammation

NM Iyengar, A Gucalp, AJ Dannenberg… - Journal of clinical …, 2016 - ncbi.nlm.nih.gov
Purpose There is growing evidence that inflammation is a central and reversible mechanism
through which obesity promotes cancer risk and progression. Methods We review recent …

Multifaceted breast cancer: the molecular connection with obesity

A Feola, S Ricci, S Kouidhi, A Rizzo… - Journal of Cellular …, 2017 - Wiley Online Library
Obesity is characterized by a disruption in energy balance regulation that results in an
excess accumulation of body fat. Its increasing prevalence poses a major public health …

The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis

A Kulkarni, LW Bowers - Cellular and Molecular Life Sciences, 2021 - Springer
Obesity has been linked to an increased risk of and a worse prognosis for several types of
cancer. A number of interrelated mediators contribute to obesity's pro-tumor effects …

[HTML][HTML] Obesity modulates the immune macroenvironment associated with breast cancer development

A Núñez-Ruiz, F Sánchez-Brena, C López-Pacheco… - PLoS …, 2022 - journals.plos.org
Growing evidence demonstrates a strong correlation between obesity and an increased risk
of breast cancer, although the mechanisms involved have not been completely elucidated …

[HTML][HTML] Mechanistic targets and nutritionally relevant intervention strategies to break obesity–breast cancer links

XM Bustamante-Marin, JL Merlino… - Frontiers in …, 2021 - frontiersin.org
The worldwide prevalence of overweight and obesity has tripled since 1975. In the United
States, the percentage of adults who are obese exceeds 42.5%. Individuals with obesity …

[HTML][HTML] Obesity is associated with immunometabolic changes in adipose tissue that may drive treatment resistance in breast cancer: immune-metabolic …

C Savva, E Copson, PWM Johnson, RI Cutress… - Cancers, 2023 - mdpi.com
Simple Summary Obesity is associated with metabolic changes in the immunological tumour
infiltrate in breast cancer. The crosstalk between adipocytes, macrophages and …