[HTML][HTML] Targeting PP2A for cancer therapeutic modulation
Protein phosphatases play essential roles as negative regulators of kinases and signaling
cascades involved in cytoskeletal organization. Protein phosphatase 2A (PP2A) is highly …
cascades involved in cytoskeletal organization. Protein phosphatase 2A (PP2A) is highly …
LB100, a small molecule inhibitor of PP2A with potent chemo-and radio-sensitizing potential
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that plays a significant
role in mitotic progression and cellular responses to DNA damage. While traditionally …
role in mitotic progression and cellular responses to DNA damage. While traditionally …
Review of PP2A tumor biology and antitumor effects of PP2A inhibitor LB100 in the nervous system
Simple Summary Central and peripheral nervous system tumors represent a heterogenous
group of neoplasms which often demonstrate resistance to treatment. Given that these …
group of neoplasms which often demonstrate resistance to treatment. Given that these …
Altering phosphorylation in cancer through PP2A modifiers
H Johnson, S Narayan, AK Sharma - Cancer Cell International, 2024 - Springer
Abstract Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the
regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of …
regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of …
Protein phosphatase 2A as a potential target for anticancer therapy
P Kalev, AA Sablina - Anti-Cancer Agents in Medicinal …, 2011 - ingentaconnect.com
The kinase oncogenes are well-characterized drivers of cancer development, and several
targeted therapies focused on both specific and selectively nonselective kinase inhibitors …
targeted therapies focused on both specific and selectively nonselective kinase inhibitors …
Unraveling the complexity: A comprehensive analysis of the PP2A in cancer and its potential for novel targeted therapies.
D Ivovič, P Kabelíková, D Jurkovičová - Neoplasma, 2023 - search.ebscohost.com
Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase
considered a potent tumor suppressor that critically regulates diverse cellular processes …
considered a potent tumor suppressor that critically regulates diverse cellular processes …
[HTML][HTML] Targeting PP2A in cancer: Combination therapies
S Mazhar, SE Taylor, J Sangodkar, G Narla - Biochimica et Biophysica Acta …, 2019 - Elsevier
The serine/threonine phosphatase PP2A regulates a vast portion of the phosphoproteome
including pathways involved in apoptosis, proliferation and DNA damage response and …
including pathways involved in apoptosis, proliferation and DNA damage response and …
Therapeutic targeting of PP2A
Abstract Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that
regulates many cellular processes. Given the central role of PP2A in regulating diverse …
regulates many cellular processes. Given the central role of PP2A in regulating diverse …
Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options
The complexity of the phosphatase, PP2A, is being unravelled and current research is
increasingly providing information on the association of deregulated PP2A function with …
increasingly providing information on the association of deregulated PP2A function with …
Protein phosphatase 2A as a therapeutic target in small cell lung cancer
T Mirzapoiazova, G Xiao, B Mambetsariev… - Molecular cancer …, 2021 - AACR
Abstract Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the
regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many …
regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many …
