Cancer is the second most common cause of death worldwide and remains one of the
critical public health problems of our time 1. Recently, immunotherapy has considerably …

Cancer is a leading cause of mortality worldwide, with around 10 million deaths every year.
Despite huge advances due to immunotherapy, the majority of cancer patients present …

The detection and killing of neoplastic cells require coordination of a variety of antitumor
effector cells. Natural killer (NK) cells of the innate immune system are at the forefront of the …

Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …

Natural Killer (NK) cells are innate immune effectors that are primarily involved in
immunosurveillance to spontaneously eliminate malignantly transformed and virally infected …

Current insights into the molecular specificities that regulate natural killer (NK)-cell function
suggest that it might be possible to design NK-cell-based immunotherapeutic strategies …

As our understanding of the molecular mechanisms governing natural killer (NK) cell activity
increases, their potential in cancer immunotherapy is growing increasingly prominent. This …

A group of impressive immunotherapies for cancer treatment, including immune checkpoint-
blocking antibodies, gene therapy and immune cell adoptive cellular immunotherapy, have …

Highlights•NK cells play a critical role in cancer immune surveillance.•NK cellular therapy is
safe but has some limitations.•Genetic engineering strategies are being employed to …

The past decade has witnessed a burgeoning of research and further insight into the biology
and clinical applications of natural killer (NK) cells. Once thought to be simple innate cells …