Breast cancer originates primarily from the epithelial cells of the mammary gland. Repeated
mammary gland expansion and degeneration are accompanied by an increased risk of …

Although not obligatory, many breast cancers appear to develop through a series of
premalignant stages histologically defined as atypical hyperplasia and carcinoma in situ …

The genomic revolution has fundamentally changed our perception of breast cancer. It is
now apparent from DNA-based massively parallel sequencing data that at the genomic …

Breast cancer is the most common cancer among women worldwide, costing the lives of
millions of women around the world. Despite the enormous research by scientists, screening …

With the rapid development of next-generation sequencing, deeper insights are being
gained into the molecular evolution that underlies the development and clinical progression …

The knowledge of specific genetic changes and their biological consequences is critical to
an understanding of the natural history of breast tumors and the development of rational …

Breast cancer remains a major global health challenge. Its rising incidence is attributed to
factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug …

Background: The recent surge of next generation sequencing of breast cancer genomes has
enabled development of comprehensive catalogues of somatic mutations and expanded the …

The continuing advancement of sequencing technologies has made the systematic
identification of all driving somatic events in cancer a possibility. In the June 2012 issue of …

The recent introduction of genomic medicine and emphasis on optimizing breast cancer risk
reduction mortalities has provided opportunities for pathologists to partner with clinicians in …