[HTML][HTML] Oligonucleotide-Based Therapeutics for STAT3 Targeting in Cancer—Drug Carriers Matter

S Molenda, A Sikorska, A Florczak, P Lorenc… - Cancers, 2023 - mdpi.com
Simple Summary Activated STAT3 is an essential factor in cancer development; therefore,
blocking STAT3 may be of therapeutic benefit in multiple cancer types. Thanks to recent …

Expression and Characterization of Catalytic Domain of T Cell Protein Tyrosine Phosphatase (ΔTC-PTP)—Immunohistochemical Study of ΔTC-PTP Expressions in …

Z ZHU, SUN Mei, X ZHANG, K LIU, D SHI, J LI… - Chemical Research in …, 2007 - Elsevier
This study objective was to express and characterize the catalytic domain of the human T
cell protein tyrosine phosphatase (ΔTC-PTP) and to study immunohistochemicaily the …

[HTML][HTML] Establishment of primary mouse lung adenocarcinoma cell culture

S Luo, M Sun, R Jiang, G Wang… - Oncology …, 2011 - spandidos-publications.com
Lung cancer is the most common malignant disease worldwide and is the leading cause of
death from cancer. Primary cultures derived from lung cancer are essential for …

In vivo anti-tumor effect of siRNA against STAT3 on transplanted Lewis lung cancer in mice

C WANG, R WANG, SUN Mei, J LI, GAO Nan… - Chemical Research in …, 2008 - Elsevier
This study aims at determining the therapeutic effect of knockdown of signal transducers and
activators of transcription3 (STAT3) gene expression by short interference RNA (siRNA) on …

Stat3 pathway inhibitors and cancer stem cell inhibitors

Z Jiang, CJ Li, W Li, D Leggett - US Patent 10,851,075, 2020 - Google Patents
The present invention relates to a novel naphtho class of compounds as Stat3 pathway
inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat …

靶向人 STAT3 基因的 shRNA 慢病毒载体的构建

党微旗, 唐浩, 曹红, 王林, 陈婷梅 - 细胞与分子免疫学杂志, 2012 - cqvip.com
目的: 构建并鉴定靶向人转录因子STAT3 基因的shRNA 慢病毒载体. 方法:
设计合成针对人STAT3 基因的shRNA 序列, 运用基因重组技术将其插入到含U6 …

STAT3 反义核酸对 HL-60 细胞周期及 c-myc mRNA 表达的影响

吴明彩, 蒋明 - 生物学杂志, 2009 - cqvip.com
实验分反义组, 无义组, 脂质体组, 空白组, 转染后, 应用四唑盐(MTT) 比色法分析细胞增殖率,
流式细胞仪检测细胞周期, RT-PCR 检测细胞中STAT3 mRNA 和c-myc mRNA 的表达 …