Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …

The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …

Purpose Anti-inflammatory and barrier-protective properties have been attributed to
proanthocyanidins in the context of intestinal dysfunction, however little information is …

Colon cancer is accompanied by a decrease of epithelial barrier properties, which are
determined by tight junction (TJ) proteins between adjacent epithelial cells. The aim of the …

Recently it has been reported that the tumor adjacent colon tissues of 1, 2-
dymethylhydrazine induced (DMH)-rats revealed a high paracellular permeability. We …

Dimethylhydrazine (DMH) is a plant toxicant that enters the food web through the diet. It is
biotransformed into azoxymethane, a colon carcinogen, during the first hepatic passage. In …

Introduction: Diseases such as celiac disease, environmental enteric dysfunction, infectious
gastroenteritis, type II diabetes and inflammatory bowel disease are associated with …

The incidence of colorectal cancer in different parts of the large intestine is not the same, as
tumors more often appear in the distal part of the colon compared to the proximal one. The …

Red and processed meat consumption has been strongly related to increase the risk of
colorectal cancer (CRC), although its impact is largely unknown. Hemin, an iron-containing …

The colon barrier function is provided by the selective permeability of colonocytes and tight
junctions between adjacent epithelial cells. The well-pronounced barrier properties of the …