Molecular targeted therapy: Treating cancer with specificity
Molecular targeted therapies are revolutionized therapeutics which interfere with specific
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …
[HTML][HTML] Clinical pharmacokinetics and pharmacodynamics of immune checkpoint inhibitors
Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical impact in
improving overall survival of several malignancies associated with poor outcomes; however …
improving overall survival of several malignancies associated with poor outcomes; however …
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
M Caskey, F Klein, JCC Lorenzi, MS Seaman… - Nature, 2015 - nature.com
HIV-1 immunotherapy with a combination of first generation monoclonal antibodies was
largely ineffective in pre-clinical and clinical settings and was therefore abandoned …
largely ineffective in pre-clinical and clinical settings and was therefore abandoned …
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
SAA Kooijmans, LAL Fliervoet, R Van Der Meel… - Journal of Controlled …, 2016 - Elsevier
Extracellular vesicles (EVs) are increasingly being recognized as candidate drug delivery
systems due to their ability to functionally transfer biological cargo between cells. However …
systems due to their ability to functionally transfer biological cargo between cells. However …
Concurrent immune checkpoint inhibitors and stereotactic radiosurgery for brain metastases in non-small cell lung cancer, melanoma, and renal cell carcinoma
Purpose To characterize the effect of concurrent stereotactic radiosurgery–stereotactic
radiation therapy (SRS-SRT) and immune checkpoint inhibitors on patient outcomes and …
radiation therapy (SRS-SRT) and immune checkpoint inhibitors on patient outcomes and …
Plants as sources of natural and recombinant anti-cancer agents
JF Buyel - Biotechnology advances, 2018 - Elsevier
Herbal remedies were the first medicines used by humans due to the many
pharmacologically active secondary metabolites produced by plants. Some of these …
pharmacologically active secondary metabolites produced by plants. Some of these …
Monoclonal antibodies in cancer immunotherapy
Nowadays, in cancer treatments, immunotherapy which can be classified as a cancer type
specific therapy is more popular than non-specific therapy methods such as surgery …
specific therapy is more popular than non-specific therapy methods such as surgery …
[HTML][HTML] Gene therapy for cancer: present status and future perspective
MH Amer - Molecular and cellular therapies, 2014 - Springer
Advancements in human genomics over the last two decades have shown that cancer is
mediated by somatic aberration in the host genome. This discovery has incited enthusiasm …
mediated by somatic aberration in the host genome. This discovery has incited enthusiasm …
[HTML][HTML] Antibody therapeutics and immunoregulation in cancer and autoimmune disease
M Yasunaga - Seminars in cancer biology, 2020 - Elsevier
Cancer and autoimmune disease are closely related, and many therapeutic antibodies are
widely used in clinics for the treatment of both diseases. Among them, the anti-CD20 …
widely used in clinics for the treatment of both diseases. Among them, the anti-CD20 …
Overlooked benefits of using polyclonal antibodies
CA Ascoli, B Aggeler - Biotechniques, 2018 - Future Science
The benefits of polyclonal antibodies as tools for assay-specific target discovery and
detection are numerous. As the future of basic research, diagnostics and biomarker …
detection are numerous. As the future of basic research, diagnostics and biomarker …