Albumin is a versatile drug carrier in anti-cancer drug delivery system and it also has an
actively targeting capacity to tumors. Recently, nanoparticle albumin-bound (nab™) paclitaxel (…

The objective of this study is to compare two different dissolution-enhancing strategies, solid
dispersion (SD) and micronized techniques, for improving oral absorption of poorly soluble …

Five peptidomimetic prodrugs of didanosine (DDI) were synthesized and designed to improve
bioavailability of DDI following oral administration via targeting intestinal oligopeptide …

The purpose of the study was to prepare and characterize nanosuspensions that can maintain
high and extended supersaturation to improve the dissolution and absorption of poorly …

For the accurate prediction of in vivo hepatic clearance or drug–drug interaction potential
through in vitro microsomal metabolic data, it is essential to evaluate the fraction unbound in …

The first-principle, quantitative structure–hepatic clearance relationship for 50 drugs was
constructed based on selected molecular descriptors calculated by TSAR software. The R 2 of …

A rapid, sensitive and selective ultra-performance liquid chromatography–tandem mass
spectrometry (UPLC–MS/MS) method with hydrophilic interaction chromatography has been …

The urgent need for effective cancer treatments, particularly for advanced and relapsed cases
in which standard therapies are inadequate, has spurred the development of innovative …

In order to study the in vivo performance and in vitro cytotoxicity of 10-hydroxycamptothecin (10-HCPT)
nanosuspension developed in our previous work. For investigating the …

Clinical pregnancies increasingly end in recurrent miscarriage (RM) during the first trimester,
with genetic factors shouldering the main responsibility. MicroRNAs (miRNAs) regulate …