The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to
be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and …

Although microRNAs (miRNAs) are key regulators of gene expression in normal human
physiology and disease, transcriptional regulation of miRNAs is poorly understood, because …

Spectrally distinct fluorophores are desired for multiplexed bioimaging. In particular,
monitoring biological processes in living mammals needs fluorophores that operate in the ‘tissue-…

In our in-depth analysis carried out by the Illumina Solexa massive parallel signature
sequencing, microRNA-99a (miR-99a) was found to be the sixth abundant microRNA in the …

Mammalian nuclei contain three different RNA polymerases defined by their characteristic
locations and drug sensitivities; polymerase I is found in nucleoli, and polymerases II and III in …

Aberrant expression and/or activity of members of the Src family of nonreceptor protein
tyrosine kinases (SFK) are commonly observed in progressive stages of human tumors. In …

In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to
immunotherapy such as interferon-α (IFN-α) would be very useful in the clinic. We found that …

The development and application of bioenergy and biofuels conversion technology can
play a significant role for the production of renewable and sustainable energy sources in the …

PRMT5 (protein arginine methyltransferase 5) is an enzyme that catalyses transfer of methyl
groups from S-adenosyl methionine to the arginine residues of histones or non-histone …

The transcriptional coactivator p300 shows physical and functional interactions with a
diverse group of activators and contains an intrinsic acetyltransferase activity whose exact …