User profiles for Yuzhou Chang
 | Yuzhou ChangJoint Post Doc researcher (OSU/BIDMC) Verified email at osu.edu Cited by 1218 |
[HTML][HTML] scGNN is a novel graph neural network framework for single-cell RNA-Seq analyses
Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and
dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from …
dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from …
[HTML][HTML] Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s
disease (AD), but little is known about the molecular mechanisms underlying this regional …
disease (AD), but little is known about the molecular mechanisms underlying this regional …
[HTML][HTML] SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
…, S Li, Y Zhou, F Wang, X Guo, S Deng, Y Chang… - Nature …, 2018 - nature.com
Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance,
but the mechanisms regulating the stability and function of Treg cells have not been fully …
but the mechanisms regulating the stability and function of Treg cells have not been fully …
A shared disease-associated oligodendrocyte signature among multiple CNS pathologies
Alzheimer’s disease (AD) is a complex neurodegenerative disease, perturbing neuronal and
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped …
non-neuronal cell populations. In this study, using single-cell transcriptomics, we mapped …
Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer
Sex bias exists in the development and progression of nonreproductive organ cancers, but
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …
the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual …
[HTML][HTML] Single-cell biological network inference using a heterogeneous graph transformer
Single-cell multi-omics (scMulti-omics) allows the quantification of multiple modalities
simultaneously to capture the intricacy of complex molecular mechanisms and cellular …
simultaneously to capture the intricacy of complex molecular mechanisms and cellular …
Integrative methods and practical challenges for single-cell multi-omics
Fast-developing single-cell multimodal omics (scMulti-omics) technologies enable the
measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA …
measurement of multiple modalities, such as DNA methylation, chromatin accessibility, RNA …
[HTML][HTML] Dimension-agnostic and granularity-based spatially variable gene identification using BSP
Identifying spatially variable genes (SVGs) is critical in linking molecular cell functions with
tissue phenotypes. Spatially resolved transcriptomics captures cellular-level gene expression …
tissue phenotypes. Spatially resolved transcriptomics captures cellular-level gene expression …
[HTML][HTML] Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology
Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes
coronavirus disease 2019 (COVID-19) through direct lysis of infected lung epithelial cells, which …
coronavirus disease 2019 (COVID-19) through direct lysis of infected lung epithelial cells, which …
Wolframin is a novel regulator of tau pathology and neurodegeneration
Selective neuronal vulnerability to protein aggregation is found in many neurodegenerative
diseases including Alzheimer’s disease (AD). Understanding the molecular origins of this …
diseases including Alzheimer’s disease (AD). Understanding the molecular origins of this …