Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer
chemotherapies. The mechanisms of MDR and the approaches to test MDR have been …

Following dramatic success in many types of advanced solid tumors, interest in
immunotherapy for the treatment of colorectal cancer (CRC) is increasingly growing. Given the …

Obesity presents a major health hazard of the 21st century. It promotes co-morbid diseases
such as heart disease, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and …

MicroRNAs play key roles in tumor metastasis. Here, we describe the regulation and function
of miR-218 in gastric cancer (GC) metastasis. miR-218 expression is decreased along with …

Objectives We aimed to characterise the microbial changes associated with histological
stages of gastric tumourigenesis. Design We performed 16S rRNA gene analysis of gastric …

Metabolic hormones, such as leptin, alter the input organization of hypothalamic circuits 1 , 2
, 3 , resulting in increased pro-opiomelanocortin (POMC) tone, followed by decreased food …

The fasting-activated longevity protein sirtuin 1 (SirT1, ref. 1 ) promotes gluconeogenesis in
part, by increasing transcription of the key gluconeogenic genes pepck1 and g6pase 2 , 3 , …

Mitochondrial morphology is dynamically remodeled by fusion and fission in cells, and
dysregulation of this process is closely implicated in tumorigenesis. However, the mechanism by …

Background & Aims Gasdermin D (GSDMD)-executed programmed necrosis is involved in
inflammation and controls interleukin (IL)-1β release. However, the role of GSDMD in non-…

Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis
and drug resistance with non-coding RNAs (ncRNAs) playing pivotal roles. We previously …