The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis. …

We comprehensively analyzed clinical, genomic, and transcriptomic data of a cohort of 465
primary triple-negative breast cancer (TNBC). PIK3CA mutations and copy-number gains of …

Treatment of triple-negative breast cancer (TNBC) remains challenging. Deciphering the
orchestration of metabolic pathways in regulating ferroptosis will provide new insights into …

Immunotherapy has achieved limited success in patients with triple-negative breast cancer (TNBC),
an aggressive disease with a poor prognosis. Commensal microbiota have been …

Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Triple-negative breast cancer (TNBC) remains an unmet medical challenge. We investigated
metabolic dysregulation in TNBCs by using our multi-omics database (n = 465, the largest …

Metabolic reprogramming is a hallmark of cancer. However, systematic characterizations of
metabolites in triple-negative breast cancer (TNBC) are still lacking. Our study profiled the …

Mis-regulated RNA modifications promote the processing and translation of oncogenic mRNAs
to facilitate cancer progression, while the molecular mechanisms remain unclear. Here …

Triple-negative breast cancer (TNBC) is a highly heterogeneous disease, and molecular
subtyping may result in improved diagnostic precision and targeted therapies. Our previous …

Purpose: The tumor microenvironment has a profound impact on prognosis and immunotherapy.
However, the landscape of the triple-negative breast cancer (TNBC) microenvironment …