[HTML][HTML] Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types
C Wang, Y Gu, K Zhang, K Xie, M Zhu, N Dai… - Nature …, 2016 - nature.com
Cancer-testis (CT) genes represent the similarity between the processes of spermatogenesis
and tumorigenesis. It is possible that their selective expression pattern can help identify …
and tumorigenesis. It is possible that their selective expression pattern can help identify …
The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription
A Xia, W Yuan, Q Wang, J Xu, Y Gu, L Zhang, C Chen… - Nature Cancer, 2022 - nature.com
Cancer-testis (CT) genes participate in the initiation and progression of cancer, but the role
of CT-associated long non-coding RNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) is …
of CT-associated long non-coding RNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) is …
[HTML][HTML] In vivo self-assembled small RNAs as a new generation of RNAi therapeutics
…, Y Su, Y Ye, X Hu, W Cheng, J Wu, Y Wang, Y Gu… - Cell research, 2021 - nature.com
RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs
and delivery with artificial vehicles or conjugated ligands; both have not solved the problem …
and delivery with artificial vehicles or conjugated ligands; both have not solved the problem …
[PDF][PDF] Analyses of rare predisposing variants of lung cancer in 6,004 whole genomes in Chinese
…, J Fan, H Ma, C Chen, M An, J Zhang, C Yan, Y Gu… - Cancer Cell, 2022 - cell.com
We present the largest whole-genome sequencing (WGS) study of non-small cell lung
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …
[PDF][PDF] Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice
…, R Zheng, X Yang, Y Gao, H Wu, M Lv, Y Gu… - The American Journal of …, 2021 - cell.com
Multiple morphological abnormalities of the sperm flagella (MMAF)-induced
asthenoteratozoospermia is a common cause of male infertility. Previous studies have identified …
asthenoteratozoospermia is a common cause of male infertility. Previous studies have identified …
Leukocyte telomere length in children born following blastocyst-stage embryo transfer
C Wang, Y Gu, J Zhou, J Zang, X Ling, H Li, L Hu… - Nature medicine, 2022 - nature.com
Perinatal and childhood adverse outcomes associated with assisted reproductive technology
(ART) has been reported, but it remains unknown whether the initial leukocyte telomere …
(ART) has been reported, but it remains unknown whether the initial leukocyte telomere …
[HTML][HTML] Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming
D Chong, Y Gu, T Zhang, Y Xu, D Bu, Z Chen, N Xu… - Cell Discovery, 2022 - nature.com
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the
increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a …
increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a …
[HTML][HTML] Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients
Chinese lung cancer patients have distinct epidemiologic and genomic features, highlighting
the presence of specific etiologic mechanisms other than smoking. Here, we present a …
the presence of specific etiologic mechanisms other than smoking. Here, we present a …
Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma
…, Q Sun, X Zhang, N Qin, Z Pu, Y Gu… - Cancer …, 2022 - Wiley Online Library
Background Epigenetic alterations have been shown to contribute immensely to human
carcinogenesis. Dynamic and reversible N6‐methyladenosine (m6A) RNA modification …
carcinogenesis. Dynamic and reversible N6‐methyladenosine (m6A) RNA modification …
[PDF][PDF] Multi-omics profiling visualizes dynamics of cardiac development and functions
Y Gu, Y Zhou, S Ju, X Liu, Z Zhang, J Guo, J Gao… - Cell Reports, 2022 - cell.com
Cardiogenesis is a tightly regulated dynamic process through a continuum of differentiation
and proliferation events. Key factors and pathways governing this process remain …
and proliferation events. Key factors and pathways governing this process remain …