[HTML][HTML] Systematic identification of genes with a cancer-testis expression pattern in 19 cancer types

C Wang, Y Gu, K Zhang, K Xie, M Zhu, N Dai… - Nature …, 2016 - nature.com
Cancer-testis (CT) genes represent the similarity between the processes of spermatogenesis
and tumorigenesis. It is possible that their selective expression pattern can help identify …

The cancer-testis lncRNA lnc-CTHCC promotes hepatocellular carcinogenesis by binding hnRNP K and activating YAP1 transcription

A Xia, W Yuan, Q Wang, J Xu, Y Gu, L Zhang, C Chen… - Nature Cancer, 2022 - nature.com
Cancer-testis (CT) genes participate in the initiation and progression of cancer, but the role
of CT-associated long non-coding RNAs (CT-lncRNAs) in hepatocellular carcinoma (HCC) is …

[HTML][HTML] In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

…, Y Su, Y Ye, X Hu, W Cheng, J Wu, Y Wang, Y Gu… - Cell research, 2021 - nature.com
RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs
and delivery with artificial vehicles or conjugated ligands; both have not solved the problem …

[PDF][PDF] Analyses of rare predisposing variants of lung cancer in 6,004 whole genomes in Chinese

…, J Fan, H Ma, C Chen, M An, J Zhang, C Yan, Y Gu… - Cancer Cell, 2022 - cell.com
We present the largest whole-genome sequencing (WGS) study of non-small cell lung
cancer (NSCLC) to date among 6,004 individuals of Chinese ancestry, coupled with 23,049 …

[PDF][PDF] Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice

…, R Zheng, X Yang, Y Gao, H Wu, M Lv, Y Gu… - The American Journal of …, 2021 - cell.com
Multiple morphological abnormalities of the sperm flagella (MMAF)-induced
asthenoteratozoospermia is a common cause of male infertility. Previous studies have identified …

Leukocyte telomere length in children born following blastocyst-stage embryo transfer

C Wang, Y Gu, J Zhou, J Zang, X Ling, H Li, L Hu… - Nature medicine, 2022 - nature.com
Perinatal and childhood adverse outcomes associated with assisted reproductive technology
(ART) has been reported, but it remains unknown whether the initial leukocyte telomere …

[HTML][HTML] Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

D Chong, Y Gu, T Zhang, Y Xu, D Bu, Z Chen, N Xu… - Cell Discovery, 2022 - nature.com
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the
increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a …

[HTML][HTML] Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients

C Wang, R Yin, J Dai, Y Gu, S Cui, H Ma… - Nature …, 2018 - nature.com
Chinese lung cancer patients have distinct epidemiologic and genomic features, highlighting
the presence of specific etiologic mechanisms other than smoking. Here, we present a …

Gene amplification‐driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A‐YTHDF2‐dependent in lung adenocarcinoma

…, Q Sun, X Zhang, N Qin, Z Pu, Y Gu… - Cancer …, 2022 - Wiley Online Library
Background Epigenetic alterations have been shown to contribute immensely to human
carcinogenesis. Dynamic and reversible N6‐methyladenosine (m6A) RNA modification …

[PDF][PDF] Multi-omics profiling visualizes dynamics of cardiac development and functions

Y Gu, Y Zhou, S Ju, X Liu, Z Zhang, J Guo, J Gao… - Cell Reports, 2022 - cell.com
Cardiogenesis is a tightly regulated dynamic process through a continuum of differentiation
and proliferation events. Key factors and pathways governing this process remain …