Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading
cause of cancer-related deaths worldwide. Although the prognosis of patients with HCC is …

Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy
for combating many types of cancer and viral infection. However, exhaustion of antigen-…

Avoiding the immune rejection of transplanted T cells is central to the success of allogeneic
cancer immunotherapies. One solution to protecting T-cell grafts from immune rejection …

Experimental autoimmune encephalomyelitis (EAE) is caused by activation of myelin Ag-reactive
CD4+ T cells. In the current study, we tested a strategy to prevent EAE by pretreatment …

The effectiveness of chimaeric antigen receptor (CAR) T-cell immunotherapies against solid
tumours relies on the accumulation, proliferation and persistency of T cells at the tumour site…

Limited T cell availability and proliferative exhaustion present major barriers to successful T
cell-based immunotherapies and may potentially be overcome through the use of "…

The use of allogeneic, pluripotent stem‐cell‐derived immune cells for cancer immunotherapy
has been the subject of recent clinical trials. In Japan, investigator‐initiated clinical trials …

Dendritic cell (DC) vaccine–based immunotherapy for glioblastoma multiforme (GBM) has
shown apparent benefit in animal experiments and early-phase clinical trials, but the survival …

We developed a method to generate dendritic cells (DCs) from mouse embryonic stem (ES)
cells. We cultured ES cells for 10 days on feeder cell layers of OP9, in the presence of …

Vα24 invariant natural killer T (iNKT) cells are a subset of T lymphocytes implicated in the
regulation of broad immune responses. They recognize lipid antigens presented by CD1d on …