Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome
Y Liu, Y Fang, X Chen, Z Wang, X Liang, T Zhang… - Science …, 2020 - science.org
Cytokine release syndrome (CRS) counteracts the effectiveness of chimeric antigen receptor
(CAR) T cell therapy in cancer patients, but the mechanism underlying CRS remains …
(CAR) T cell therapy in cancer patients, but the mechanism underlying CRS remains …
[HTML][HTML] Reactive oxygen species regulate T cell immune response in the tumor microenvironment
Reactive oxygen species (ROS) produced by cellular metabolism play an important role as
signaling messengers in immune system. ROS elevated in the tumor microenvironment are …
signaling messengers in immune system. ROS elevated in the tumor microenvironment are …
CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer
J Li, L Wang, X Chen, L Li, Y Li, Y Ping, L Huang… - …, 2017 - Taylor & Francis
CD39/CD73-adenosine pathway has been recently defined as an important tumor-induced
immunosuppressive mechanism. We here documented a fraction of CD11b + CD33 + …
immunosuppressive mechanism. We here documented a fraction of CD11b + CD33 + …
Metformin-induced reduction of CD39 and CD73 blocks myeloid-derived suppressor cell activity in patients with ovarian cancer
…, C Zhang, D Yue, G Qin, T Zhang, F Li, X Chen… - Cancer research, 2018 - AACR
Metformin is a broadly prescribed drug for type 2 diabetes that exerts antitumor activity, yet
the mechanisms underlying this activity remain unclear. We show here that metformin …
the mechanisms underlying this activity remain unclear. We show here that metformin …
[HTML][HTML] Bromo- and iodo-bridged building units in metal-organic frameworks for enhanced carrier transport and CO2 photoreduction by water vapor
X Chen, C Peng, W Dan, L Yu, Y Wu, H Fei - Nature Communications, 2022 - nature.com
Organolead halide hybrids have many promising attributes for photocatalysis, eg. tunable
bandgaps and excellent carrier transport, but their instability constraints render them …
bandgaps and excellent carrier transport, but their instability constraints render them …
IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer
…, S Liu, D Wang, Q Gao, S Ji, X Chen… - … Journal of Cancer, 2019 - Wiley Online Library
Tumor‐associated macrophages (TAMs), key immune cells in the tumor microenvironment,
are shown to be closely correlated with the progression of non‐small cell lung cancer (…
are shown to be closely correlated with the progression of non‐small cell lung cancer (…
[HTML][HTML] Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC
Q Gao, S Wang, X Chen, S Cheng, Z Zhang… - … for immunotherapy of …, 2019 - Springer
Background Chemotherapy combined with immunotherapy becomes the main trend in lung
cancer intervention; however, how chemotherapy promotes the immune function remains …
cancer intervention; however, how chemotherapy promotes the immune function remains …
Metal–organic framework enhances aggregation-induced fluorescence of chlortetracycline and the application for detection
L Yu, H Chen, J Yue, X Chen, M Sun, H Tan… - Analytical …, 2019 - ACS Publications
The development of an analytical method for selective and sensitive detection of chlortetracycline
(CTC), an often overused broad spectrum antibiotic, is important and challenging in …
(CTC), an often overused broad spectrum antibiotic, is important and challenging in …
A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells
…, T Ji, H Zhang, W Dong, X Chen, P Xu, D Chen… - Nature cell …, 2018 - nature.com
CD8 + memory T (Tm) cells are fundamental for protective immunity against infections and
cancers 1 , 2 , 3 , 4 – 5 . Metabolic activities are crucial in controlling memory T-cell …
cancers 1 , 2 , 3 , 4 – 5 . Metabolic activities are crucial in controlling memory T-cell …
[HTML][HTML] 4D-MRI driven MR-guided online adaptive radiotherapy for abdominal stereotactic body radiation therapy on a high field MR-Linac: Implementation and initial …
…, E Ahunbay, X Chen, NJ Mickevicius, GP Chen… - Clinical and translational …, 2020 - Elsevier
Background and purpose In this report, we describe our implementation and initial clinical
experience using 4D-MRI driven MR-guided online adaptive radiotherapy (MRgOART) for …
experience using 4D-MRI driven MR-guided online adaptive radiotherapy (MRgOART) for …
