BCR-ABL tyrosine kinase inhibitors in the treatment of Philadelphia chromosome positive chronic myeloid leukemia: a review
X An, AK Tiwari, Y Sun, PR Ding, CR Ashby Jr… - Leukemia research, 2010 - Elsevier
Chronic Myeloid Leukemia (CML) is a clonal disease characterized by the presence of the
Philadelphia (Ph+) chromosome and its oncogenic product, BCR-ABL, a constitutively active …
Philadelphia (Ph+) chromosome and its oncogenic product, BCR-ABL, a constitutively active …
[HTML][HTML] Regulation of multidrug resistance by microRNAs in anti-cancer therapy
X An, C Sarmiento, T Tan, H Zhu - Acta Pharmaceutica Sinica B, 2017 - Elsevier
Multidrug resistance (MDR) remains a major clinical obstacle to successful cancer treatment.
Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of …
Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of …
Additive manufacturing of self-healing elastomers
Nature excels in both self-healing and 3D shaping; for example, self-healable human
organs feature functional geometries and microstructures. However, tailoring man-made self-…
organs feature functional geometries and microstructures. However, tailoring man-made self-…
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
Regulatory T cells (T reg cells) are required for peripheral tolerance. Evidence indicates that
T reg cells can adopt specialized differentiation programs in the periphery that are …
T reg cells can adopt specialized differentiation programs in the periphery that are …
[PDF][PDF] Blimp-1 transcription factor is required for the differentiation of effector CD8+ T cells and memory responses
In response to viral infection, naive CD8 + T cells proliferate and differentiate into cytotoxic
and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1, a …
and cytokine-producing effector cells. Here we showed that the transcription factor Blimp-1, a …
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells
A Vasanthakumar, K Moro, A Xin, Y Liao, R Gloury… - Nature …, 2015 - nature.com
Foxp3 + regulatory T (T reg ) cells in visceral adipose tissue (VAT-T reg cells) are functionally
specialized tissue-resident cells that prevent obesity-associated inflammation and …
specialized tissue-resident cells that prevent obesity-associated inflammation and …
The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells
During immune responses, T cells are subject to clonal competition, which leads to the
predominant expansion of high-affinity clones; however, there is little understanding of how this …
predominant expansion of high-affinity clones; however, there is little understanding of how this …
Exposure of soil collembolans to microplastics perturbs their gut microbiota and alters their isotopic composition
Abstract Effects of microplastics on aquatic organisms have been widely studied in recent
years but effects on soil biota, and especially on the gut microbiota of soil animals, remain …
years but effects on soil biota, and especially on the gut microbiota of soil animals, remain …
Methanol synthesis from CO2 hydrogenation with a Cu/Zn/Al/Zr fibrous catalyst
AN Xin, ZUO Yizan, Q Zhang, W Jinfu - Chinese Journal of Chemical …, 2009 - Elsevier
A highly active Cu/Zn/Al/Zr fibrous catalyst was developed for methanol synthesis from CO 2
hydrogenation. Various factors that affect the activity of the catalyst, including the reaction …
hydrogenation. Various factors that affect the activity of the catalyst, including the reaction …
Nitrogen loss through anaerobic ammonium oxidation coupled to iron reduction from paddy soils in a chronosequence
Anaerobic ammonium oxidation coupled to iron(III) reduction (termed Feammox) with dinitrogen,
nitrite, or nitrate as the end-product is a recently discovered process of nitrogen cycling. …
nitrite, or nitrate as the end-product is a recently discovered process of nitrogen cycling. …
