The lack of response to treatment in most lung cancer patients suggests the value of
broadening the benefit of anti–PD-1/PD-L1 monotherapy. Judicious dosing of antiangiogenic …

Autoinducer-2 (AI-2) is a quorum sensing signal that mediates communication within and
between many bacterial species. However, its known receptors (LuxP and LsrB families) are …

Trichoderma viride was utilized to ferment the defatted rice bran (DRB), and soluble dietary
fiber was prepared before and after fermentation, named as B-SDF and F-SDF, respectively. …

Immune checkpoint inhibitors targeting the programmed cell death receptor/ligand 1 (PD‐1/PD‐L1)
pathway have profoundly improved the clinical management of non‐small‐cell lung …

Graphene oxide (GO) and GO-based materials have shown excellent adsorption properties
because of bounteous structure and rich oxygen functional groups. Many studies have …

Since late 2010, porcine epidemic diarrhea virus (PEDV) has rapidly disseminated all over
the China and caused considerable morbidity and high mortality (up to 100%) in neonatal …

Joint diseases like osteoarthritis usually are accompanied with inflammatory processes, in
which pro‐inflammatory cytokines mediate the generation of intracellular reactive oxygen …

MLN4924 is an investigational small-molecule inhibitor of the NEDD8-activating enzyme (NAE)
in phase I clinical trials. NAE inhibition prevents the ubiquitination and proteasomal …

Breast cancer (BC) is the most common cancer in women worldwide. Although substantial
progress has been made in the diagnosis and treatment of breast cancer, the efficacy and …

Multiple pathways have been proposed to explain how proteasome inhibition induces cell
death, but mechanisms remain unclear. To approach this issue, we performed a genome-wide …